| 赵桂芳,熊 杰,叶 挺.阿瑞匹坦预防阿霉素联合异环磷酰胺方案化疗后呕吐的临床观察[J].肿瘤学杂志,2017,23(9):802-806. |
| 阿瑞匹坦预防阿霉素联合异环磷酰胺方案化疗后呕吐的临床观察 |
| Clinical Observation of Aprepitant in the Antiemetic Treatment of Doxorubicin and Ifosfamide Regimen Induced Vomiting |
| 投稿时间：2016-11-29 |
| DOI：10.11735/j.issn.1671-170X.2017.09.B013 |
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| 中文关键词: 骨肉瘤 软组织肉瘤 阿瑞匹坦 化疗 恶心 呕吐 |
| 英文关键词:osteosarcoma soft tissue sarcoma aprepitant chemotherapy nausea vomiting |
| 基金项目:华中科技大学同济医学院研究型临床医师资助计划（［2017］4号） |
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| 中文摘要: |
| 摘 要：［目的］ 观察阿瑞匹坦预防阿霉素联合异环磷酰胺（AI）方案化疗后呕吐的疗效及安全性。［方法］ 将接受AI化疗方案的80例骨肉瘤和软组织肉瘤患者随机分为两组，阿瑞匹坦组予以三联（阿瑞匹坦、帕诺洛司琼、地塞米松）止吐方案、对照组予以二联（帕洛诺司琼、地塞米松）止吐方案，比较两组患者恶心、呕吐的控制情况，同时观察阿瑞匹坦的不良反应。［结果］ 急性观察期，阿瑞匹坦组和对照组的完全缓解(complete response，CR) 率分别为84.6%和63.4%（P＜0.05）；迟发性观察期，阿瑞匹坦组CR率高于对照组（74.4% vs. 51.2%，P＜0.05）；在总观察期，阿瑞匹坦组CR率亦显著性高于对照组（69.2% vs. 46.3%，P＜0.05）；而两组的不良反应发生率无明显差异（P＞0.05）。［结论］ 阿瑞匹坦联合帕洛诺司琼及地塞米松能有效预防AI化疗方案引起的恶心呕吐，且不良反应可耐受。 |
| 英文摘要: |
| Abstract：［Objective］ To evaluate the antiemetic efficiency and safety of aprepitant against AI regimen chemotherapy based on doxorubicin and ifosfamide induced vomiting. ［Methods］ Eighty patients confirmed malignant bone and soft tissue sarcoma and received AI regimen chemotherapy were divided into two groups randomly. The aprepitant group had a 3-drug combination (aprepitant，palonosetron and dexamethasone). The control group received a 2-drug combination (palonosetron and dexamethasone).The control of chemotherapy induced nausea and vomiting and the adverse effects were monitored. ［Results］ The incidence of complete response rate in aprepitant group and control group were 84.6% versus 63.4%(P＜0.05) for acute phase. The complete control rate in aprepitant group were higher than that in control group (74.4% vs. 51.2%，P＜0.05) for delayed phase. The complete control rate in aprepitant group were also significantly higher than that in control group(69.2% vs. 46.3%，P＜0.05) for overall phase. Statistical analysis showed no difference on adverse effects of two groups. ［Conclusions］ Aprepitant，palonosetron and dexamethasone significantly prevent the AI regimen induce nausea and vomiting. The side effects of aprepitant can be tolerated and controlled. |
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