王月云,张燕茹,刘植华.深圳市女性HPV感染及血清叶酸水平与子宫颈病变的关系[J].肿瘤学杂志,2017,23(9):776-779.
深圳市女性HPV感染及血清叶酸水平与子宫颈病变的关系
Relationship Between HPV Infection,Serum Folate Levels and Cervical Lesions Among Women in Shenzhen
投稿时间:2017-04-06  
DOI:10.11735/j.issn.1671-170X.2017.09.B007
中文关键词:  人乳头瘤病毒  血清  叶酸  宫颈癌
英文关键词:human papillomavirus  serum  folate  cervical cancer
基金项目:深圳市卫计委科研计划项目(201302110)
作者单位
王月云 深圳市妇幼保健院 
张燕茹 江阴市疾病预防控制中心 
刘植华 深圳市妇幼保健院 
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中文摘要:
      摘 要:[目的] 研究深圳市女性人乳头瘤病毒(human papillomavirus,HPV)感染及血清叶酸水平与子宫颈病变的关系,为宫颈癌的预防提供理论依据。[方法] 选取2015年12月1日至2016年5月31日深圳市7家医院宫颈门诊病人为研究对象,其中,正常90人,CIN1有110例,CIN2+有136例。比较分析各组妇女HPV感染状态,血清叶酸水平及其与子宫颈病变的关系。[结果] 随着子宫颈病变程度的加深,HPV感染率逐渐升高(χ2趋势=104.351,P<0.001)。正常组、CIN1组及CIN2+三个组间血清叶酸水平的差异有统计学意义(F=4.313,P=0.014),其中,CIN2+组与正常组及CIN1组比较差异具有统计学意义(P<0.05)。三组hrHPV+者血清叶酸水平间的差异具有统计学意义(F=6.843,P<0.001)。其中,CIN2+组与正常组及CIN1组比较差异具有统计学意义(P<0.05)。[结论] 血清叶酸水平可能与子宫颈病变相关,且可能与HPV感染存在相加作用。
英文摘要:
      Abstract:[Objective] To investigate the relationship between human papillomavirus(HPV) infection,serum folate levels and cervical lesions among women in Shenzhen. [Methods] Patients attending cervical outpatient clinics of 7 hospital in Shenzhen from December 2015 to May 2016 were enrolled in the study,including 90 normal cases,110 CIN1 cases,and 136 CIN2+ cases. The relationship between HPV infection,serum folate levels and cervical lesions was analyzed. [Results] HPV positivity increased with the severity of the pathological result(χ2trend=104.351,P<0.001). The serum folic acid levels among normal,CIN1 and CIN2+ groups were significantly different(F=4.313,P=0.014);and also there was significant difference between CIN2+ and normal groups,and between CIN2+ and CIN1 groups(P<0.05). There were significant differences in serum folate levels of hrHPV+ women among normal,CIN1 and CIN2+ groups(F=6.843,P<0.001),and there was significant difference between CIN2+ and normal groups,and between CIN2+ and CIN1 groups(P<0.05). [Conclusion] Serum folic acid level may be associated with cervical lesions and HPV infection may have an addictive effect.
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