| 王月云,张燕茹,刘植华.深圳市女性HPV感染及血清叶酸水平与子宫颈病变的关系[J].肿瘤学杂志,2017,23(9):776-779. |
| 深圳市女性HPV感染及血清叶酸水平与子宫颈病变的关系 |
| Relationship Between HPV Infection，Serum Folate Levels and Cervical Lesions Among Women in Shenzhen |
| 投稿时间：2017-04-06 |
| DOI：10.11735/j.issn.1671-170X.2017.09.B007 |
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| 中文关键词: 人乳头瘤病毒 血清 叶酸 宫颈癌 |
| 英文关键词:human papillomavirus serum folate cervical cancer |
| 基金项目:深圳市卫计委科研计划项目（201302110） |
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| 中文摘要: |
| 摘 要：［目的］ 研究深圳市女性人乳头瘤病毒（human papillomavirus，HPV）感染及血清叶酸水平与子宫颈病变的关系，为宫颈癌的预防提供理论依据。［方法］ 选取2015年12月1日至2016年5月31日深圳市7家医院宫颈门诊病人为研究对象，其中，正常90人，CIN1有110例，CIN2+有136例。比较分析各组妇女HPV感染状态，血清叶酸水平及其与子宫颈病变的关系。［结果］ 随着子宫颈病变程度的加深，HPV感染率逐渐升高（χ2趋势=104.351，P<0.001）。正常组、CIN1组及CIN2+三个组间血清叶酸水平的差异有统计学意义（F=4.313，P=0.014），其中，CIN2+组与正常组及CIN1组比较差异具有统计学意义（P<0.05）。三组hrHPV+者血清叶酸水平间的差异具有统计学意义（F=6.843，P<0.001）。其中，CIN2+组与正常组及CIN1组比较差异具有统计学意义（P<0.05）。［结论］ 血清叶酸水平可能与子宫颈病变相关，且可能与HPV感染存在相加作用。 |
| 英文摘要: |
| Abstract：［Objective］ To investigate the relationship between human papillomavirus(HPV) infection，serum folate levels and cervical lesions among women in Shenzhen. ［Methods］ Patients attending cervical outpatient clinics of 7 hospital in Shenzhen from December 2015 to May 2016 were enrolled in the study，including 90 normal cases，110 CIN1 cases，and 136 CIN2+ cases. The relationship between HPV infection，serum folate levels and cervical lesions was analyzed. ［Results］ HPV positivity increased with the severity of the pathological result(χ2trend=104.351，P<0.001). The serum folic acid levels among normal，CIN1 and CIN2+ groups were significantly different(F=4.313，P=0.014)；and also there was significant difference between CIN2+ and normal groups，and between CIN2+ and CIN1 groups(P<0.05). There were significant differences in serum folate levels of hrHPV+ women among normal，CIN1 and CIN2+ groups(F=6.843，P<0.001)，and there was significant difference between CIN2+ and normal groups，and between CIN2+ and CIN1 groups(P<0.05). ［Conclusion］ Serum folic acid level may be associated with cervical lesions and HPV infection may have an addictive effect. |
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