| 王 浩,田 田,李家军.NSE与proGRP单独或并联联合检测对SCLC诊断价值的系统评价[J].肿瘤学杂志,2017,23(9):765-771. |
| NSE与proGRP单独或并联联合检测对SCLC诊断价值的系统评价 |
| Diagnostic Value of Serum NSE and/or proGRP for Small Cell Lung Cancer：A Meta-analysis |
| 投稿时间：2017-04-05 |
| DOI：10.11735/j.issn.1671-170X.2017.09.B005 |
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| 中文关键词: 小细胞肺癌 神经元特异性烯醇化酶 胃泌素释放肽前体 系统评价 |
| 英文关键词:small cell lung cancer neuron specific enolase pro-gastrin releasing peptide systematic review |
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| 摘要点击次数: 1882 |
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| 中文摘要: |
| 摘 要：［目的］ 系统评价NSE、proGRP单独及联合检测在小细胞肺癌中的临床诊断价值。［方法］ 计算机检索国内外重要数据库，按照预先制定纳入和排除标准，依据诊断研究准确性质量评价工具（QUADAS）进行质量评估，通过Meta DiSc 1.4 及STATA 12.0合并效应量，绘制综合受试者工作曲线（SROC）。［结果］ 纳入12篇文献。对小细胞肺癌诊断价值：（1）以健康组为对照 NSE、proGRP及两者联合诊断SCLC汇总受试者工作特征曲线下面积（AUC）分别为0.7186，0.8831，0.9577。Z检验显示proGRP及联合检验均优于NSE单独检验SCLC，但proGRP单独检测和联合检验对SCLC诊断无统计学差异。（2）以肺部良性疾病为对照 NSE、proGRP及两者联合诊断AUC分别为0.7226，0.8387，0.9289。Z检验表明联合检测优于proGRP单独检测，proGRP优于NSE单独检测对SCLC诊断。（3）以非小细胞肺癌为对照 NSE、proGRP及两者联合诊断AUC分别为0.7145，0.6282，0.9290。Z检验提示单独或联合检测NSE、proGRP对小细胞肺癌诊断无统计学差异。［结论］ NSE、proGRP单项检测在诊断小细胞肺癌时均具有较高的准确性，NSE和proGRP联合检测可显著提高小细胞肺癌诊断灵敏度，proGRP单独检测特异性更高。临床应根据不同目的，有选择性地合理使用NSE、proGRP单独或联合检测。 |
| 英文摘要: |
| Abstract：［Objective］ To evaluate the diagnosis value of serum neuron specific enolase(NSE) and/or pro-gastrin releasing peptide(proGRP) for small cell lung cancer(SCLC). ［Methods］ The studies on serum NSE and/or proGRP in diagnosis of SCLC were searched and QUADAS were used for quality assessment. Meta DiSc 1.4 and STATA 12.0 were used for meta-analysis. ［Results］ Twelve studies were included for analysis. Compared with healthy group，the area under the receiver operating characteristic curve(AUC) of NSE，proGRP and parallel detection for diagnosis of SCLC were 0.7186，0.8831 and 0.9577，respectively. Z test showed that proGRP and the parallel tests were better than NSE single test. There was no significant difference between proGRP and the parallel tests. Compared with benign pulmonary disease，the AUC of NSE，proGRP and parallel detection for diagnosis of SCLC were 0.7226，0.8387，0.9289. Z test showed that parallel detection was better than proGRP alone，and proGRP was better than NSE in the diagnosis of SCLC. Compared with non-small cell lung cancer(NSCLC)，the AUC of NSE，proGRP and parallel detection in diagnosis of SCLC were 0.7145，0.6282，0.9290. Z test showed that there was no difference in the diagnosis of SCLC between NSE and proGRP alone or in combination.［Conclusion］ NSE and proGRP have a high accuracy in diagnosis of small cell lung cancer. Combined detection of NSE and proGRP can significantly improve the diagnostic sensitivity，while the proGRP alone has a high specificity. For different control groups the diagnostic efficacy is different. |
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