| 陈梦圆,胡 晓,孔 月.局限期小细胞肺癌预防性全脑照射研究进展[J].肿瘤学杂志,2017,23(9):759-764. |
| 局限期小细胞肺癌预防性全脑照射研究进展 |
| Advance of Prophylactic Cranial Irradiation for Limited-stage Small Cell Lung Cancer |
| 投稿时间：2017-02-06 |
| DOI：10.11735/j.issn.1671-170X.2017.09.B004 |
|
 |
| 中文关键词: 局限期小细胞肺癌 预防性脑照射 脑转移 总生存期 |
| 英文关键词:limited-stage small cell lung cancer prophylactic cranial irradiation brain metastases overall survival |
| 基金项目: |
|
| 摘要点击次数: 1940 |
| 全文下载次数: 755 |
| 中文摘要: |
| 摘 要：小细胞肺癌（small cell lung cancer，SCLC）占肺癌的10%~20%，恶性程度高，易转移复发。SCLC具有易发生脑转移的临床生物学特征，而随着现代综合诊疗的进步，患者生存率逐渐提高，相应的脑转移发生率也逐渐增加。治疗后完全缓解的局限期SCLC患者可从预防性脑照射（prophylactic cranial irradiation，PCI）中获益，但高龄患者以及完全切除的早期患者行PCI的必要性，尚存在争议。此外，PCI的适用人群范围、介入时机、剂量分割、远期神经毒副作用仍有待进一步研究。全文对上述问题进行文献综述，并介绍该领域的研究进展。 |
| 英文摘要: |
| Abstract：Small cell lung cancer (SCLC) accounts for 10%~20% lung cancer. It is distinguished from other lung cancers owing to its rapid proliferation，aggressive clinical course with early metastatic dissemination. Prophylactic cranial irradiation(PCI) has been the standard of practice for patients successfully treated for limited stage small cell lung cancer for decades，particularly in patients with limited stage disease who has achieved complete response. The late neurologic sequelae may worsen quality-adjusted life expectancy for long-term survivors，as the pronounced effect of long-term neurotoxicity (NT) becomes apparent after several years. Some novel potential approaches to reduce the PCI-related late NT have recently been investigated. In addition，who should be given PCI，when and how? This review attempts to gather together evidence for improving patients’ selection and introduce the progress in this field. |
|
在线阅读
查看全文 查看/发表评论 下载PDF阅读器 |