| 代湘云,吴 涛,白 海.原发性皮肤间变大细胞淋巴瘤治疗进展[J].肿瘤学杂志,2017,23(8):711-714. |
| 原发性皮肤间变大细胞淋巴瘤治疗进展 |
| Progress in Treatment of Primary Cutaneous Anaplastic Large Cell Lymphoma |
| 投稿时间：2016-12-30 |
| DOI：10.11735/j.issn.1671-170X.2017.08.B013 |
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| 中文关键词: 间变性大细胞淋巴瘤 原发皮肤型 补骨脂素 PUVA |
| 英文关键词:anaplastic large cell lymphoma primary cutaneous psoralen psoralen plus ultraviolet-A light |
| 基金项目:甘肃省自然科学基金资助项目（145RJZA151） |
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| 中文摘要: |
| 摘 要：原发性皮肤间变大细胞淋巴瘤是间变大细胞性淋巴瘤的一种罕见类型，多见于50岁以上成年男性，临床上多以四肢单发或多发的实性结节、斑块和（或）肿块为首发表现，严重时可破溃形成溃疡，部分病损可自行消退；对于不能自愈而病灶局限者多选择手术切除或局部放疗；累及全身皮肤或皮肤以外者，多采用单药或联合化疗方案，其5～10年缓解率约90%以上，预后较好。全文就原发性皮肤间变大细胞淋巴瘤治疗进展进行综述。 |
| 英文摘要: |
| Abstract：Primary cutaneous anaplastic large cell lymphoma(PC-ALCL) is a rare type of anaplastic large cell lymphom(ALCL)，which is more likely to occur in men over the age of 50. PC-ALCL is clinically characterized by solid nodules，plaques，lumps at single or multiple limb for the first performance. Severe nodules within the plaques can form ulceration. Some lesions may subside spontaneously. Surgical resection or local radiotherapy are necessary for those which are localized or not self-healed. Multi-agent chemotherapy or mono-chemotherapy are applied for PC-ALCL involving the skin of whole body or other organs，and the 5~10 years remission rate would be 90% or more. In this article the recent progress in the treatment of primary cutaneous anaplastic large cell lymphoma is reviewed. |
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