| 董建国,江海波,任选义.小窝蛋白-1和血管内皮生长因子在膀胱尿路上皮癌中的表达及其临床意义[J].肿瘤学杂志,2017,23(8):698-701. |
| 小窝蛋白-1和血管内皮生长因子在膀胱尿路上皮癌中的表达及其临床意义 |
| Expression of Caveolin-1 and VEGF in Bladder Urothelial Carcinoma and its Clinical Significance |
| 投稿时间：2017-01-05 |
| DOI：10.11735/j.issn.1671-170X.2017.08.B010 |
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| 中文关键词: 小窝蛋白-1 血管内皮生长因子 膀胱上皮癌 组织学分级 临床分期 |
| 英文关键词:caveolin-1 vascular endothelial cell growth factor bladder urothelial carcinoma histological grade clinical stage |
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| 中文摘要: |
| 摘 要：［目的］ 探讨小窝蛋白-1(caveolin-1)和血管内皮生长因子(VEGF)在膀胱尿路上皮癌(BUC)组织中的表达及其临床意义。［方法］ 应用免疫组织化学PV-6000法检测caveolin-1和VEGF在86例BUC和13例正常膀胱黏膜组织中的表达情况并分析其相关性。［结果］ Caveolin-1和VEGF蛋白在正常膀胱黏膜呈低表达（8.7%和15.4%），在BUC组织呈高表达（59.6%和75.6%），差异均有统计学意义(P=0.003，P=0.017)。Caveolin-1在BUC组织的阳性表达率随着膀胱癌分级和分期的提高，其表达水平呈增高趋势，差异有统计学意义(P=0.005，P=0.002)。VEGF在BUC组织的阳性表达率随着BUC分级和分期的提高其表达水平亦增高，差异有统计学意义(P=0.006，P=0.002)。Caveolin-1和VEGF蛋白在BUC组织中的阳性表达呈正相关(r=0.245，P=0.023)。［结论］ Caveolin-1和VEGF在BUC组织中高表达，可作为促进BUC发生和进展的标志物。 |
| 英文摘要: |
| Abstract：［Objective］ To investigate the expression and clinical significance of caveolin-1 and vascular endothelial cell growth factor(VEGF) in bladder urothelial carcinoma(BUC). ［Methods］ The expression level of caveolin-1 and VEGF protein in 86 cases of BUC and 13 cases of normal bladder mucosa was detected by immunohistochemical PV-6000 method，and the correlation of caveolin-1 and VEGF expression with clinicopathological features of BUC was analyzed. ［Results］ The positive rate of caveolin-1 and VEGF protein in BUC(59.6% and 75.6%) was higher than that in normal bladder mucosa(8.7% and 15.4%；P=0.003 and P=0.017). The positive expression of caveolin-1 in BUC was positively correlated with the histological grades and T stages (P=0.005，P=0.002). The positive expression of VEGF in BUC was positively correlated with the histological grade and T stages(P=0.006，P=0.002). The expression of caveolin-1 and VEGF protein was positively correlated with each other in BUC(r=0.245，P=0.023). ［Conclusion］ Caveolin-1 and VEGF are highly expressed in BUC， indicating that both caveolin-1 and VEGF may promote the carcinogenesis and progression of BUC. |
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