| 徐 琛,何湘漪,张海兵.非HBV感染型与HBV感染型原发性肝细胞癌病理特征分析[J].肿瘤学杂志,2017,23(8):672-676. |
| 非HBV感染型与HBV感染型原发性肝细胞癌病理特征分析 |
| Pathologic Characteristics of Non-HBV Related and HBV Related Primary Hepatocellular Carcinoma |
| 投稿时间：2016-12-02 |
| DOI：10.11735/j.issn.1671-170X.2017.08.B005 |
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| 中文关键词: 原发性肝癌 肝细胞肝癌 乙型肝炎病毒 病理特征 |
| 英文关键词:primary liver cancer hepatocellular carcinoma HBV pathological feature |
| 基金项目:湖州市科技计划项目（2014GYB-02）；湖州市科技计划项目（2015GYB-04） |
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| 中文摘要: |
| 摘 要：［目的］ 探讨非HBV感染型和HBV感染型原发性肝细胞癌病理学特征的差异。［方法］ 回顾性分析89例经手术切除并病理证实肝细胞性肝癌患者病理资料，包括肿块大小、病灶数目、包膜完整性、卫星灶、细胞分化程度及AFP、CD34、p53、Ki-67等免疫组化染色病理学特征与HBV感染的相关性，对各病理特征进行单因素χ2检验和多因素Logistic回归分析。［结果］ 89例患者中，25例为非HBV感染型，占28.09%。单因素分析显示，肿块大小、包膜完整性、卫星灶、细胞分化程度、AFP及CD34在HBV感染组和非感染组间差异有统计学意义；多因素Logistic分析结果显示，肿块大小（χ2=10.360，P<0.01）、Edmondson分级（χ2=6.671，P=0.01）、CD34（χ2=6.671，P<0.05）及AFP（χ2=7.638，P=0.01），两组间差异具有独立性。［结论］ 非HBV感染型较HBV感染型原发性肝细胞癌具有就诊时肿块较大和相对完整的包膜、较高的分化程度、CD34和AFP低表达等相对独特的病理特征。 |
| 英文摘要: |
| Abstract：［Objective］ To compare the pathologic characteristics of non-HBV related primary hepatocellular carcinoma (PHC) with HBV related PHC. ［Methods］ The clinicopathological characteristics of 89 cases with pathologically confirmed PHC，including 25 non-HBV related cases and 64 HBV related cases，were retrospectively analyzed. The pathological data including tumor size，number of lesions，capsule integrity，satellite lesions，cell differentiation and AFP，CD34，p53，Ki-67 in immunohistochemistry，and the relationship of clinicopathological characteristics with HBV infection were analyzed by univariate and multivariate regression analysis. ［Results］ The univariate analysis showed that there were significant differences in tumor size，capsule integrity，satellite lesions，cell differentiation，AFP and CD34 levels between the two groups. Multivariate logistic analysis showed that the tumor size (χ2=10.360，P<0.01) ，Edmondson grading (χ2= 6.671，P=0.01)，CD34 (χ2=6.671，P=0.01) and AFP (χ2=7.638，P=0.01) were the independent factors associated with HBV related PHC. ［Conclusion］ Compared with HBV related PHC，non-HBV related PHC has the unique pathological features of larger tumor size，relatively complete capsule，the higher degree of differentiation and lower expression of CD34 and AFP. |
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