| 于新平,吴玉梅.宫颈癌放射治疗敏感性的相关影响因素[J].肿瘤学杂志,2017,23(7):631-635. |
| 宫颈癌放射治疗敏感性的相关影响因素 |
| Factors Associated with Radiosensitivity of Cervical Cancer |
| 投稿时间：2016-10-26 |
| DOI：10.11735/j.issn.1671-170X.2017.07.B015 |
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| 中文关键词: 宫颈癌 放射治疗 敏感性 |
| 英文关键词:cervical cancer radiation therapy radiosensitivity |
| 基金项目:国家自然科学基金（81272888） |
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| 中文摘要: |
| 摘 要：放射治疗的有效性多取决于肿瘤自身的放射敏感性。近年来，随着现代分子生物学及基因治疗学研究的不断进展，关于放射敏感性的相关研究越来越多，大多涉及到肿瘤微环境乏氧、细胞DNA损伤修复、细胞凋亡、信号传导等因素，深入了解到宫颈癌放射敏感性相关机制，可能为提高今后治疗效果提供有价值的突破点。 |
| 英文摘要: |
| Abstract：Radiation therapy plays a critical role in women with advanced-stage cervical cancer worldwide，it may be the only available treatmentin developing countries. The efficacy of radiation largely depends on the radiosensitivity of the tumor. The high radiation dose radiation may induce severe side-effectson cervical cancer，so a safe and effective radiation therapy has always been studied by gynecologist andradiologist.In recent years，with the development of the modern molecular biology and gene therapy，more and more knowledge about radiosensitivity has been gained，including the effects of hypoxia ，DNA repair，apoptosis，signal pathway and so on，making it possible to understandthemechanisms underlying the radiosensitivityof cervical cancer to achieve a better treatment outcome. In this review，some of these factors associated with the radiosensitivity of cervical cancer are discussed. |
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