| 周炳娟,黄丽娟,曹建江.Runx2和Slug在乳腺癌中的表达及意义[J].肿瘤学杂志,2017,23(7):619-622. |
| Runx2和Slug在乳腺癌中的表达及意义 |
| Expression of Runx2 and Slug in Breast Cancer and Its Significance |
| 投稿时间：2016-12-07 |
| DOI：10.11735/j.issn.1671-170X.2017.07.B012 |
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| 中文关键词: 乳腺肿瘤 Runx2 Slug 免疫组织化学 |
| 英文关键词:breast neoplasms Runx2 Slug immunohistochemistry |
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| 中文摘要: |
| 摘 要：［目的］ 探讨Runx2和Slug在乳腺癌组织中的表达及临床意义。［方法］ 采用免疫组化法检测Runx2和Slug在105例乳腺浸润性导管癌和105例癌旁乳腺组织中的表达情况，分析其与乳腺癌临床病理特征间的关系。［结果］ 乳腺浸润性导管癌组织中Runx2及Slug的阳性表达率分别为69.52%（73/105）和42.86（45/105），显著性高于癌旁乳腺组织（P<0.05）。Runx2和Slug在乳腺浸润性导管癌中的表达均与ER呈负相关（r=-0.302，P<0.01；r=-0.368，P<0.01）。Runx2和Slug表达与乳腺癌的组织学分级、淋巴结转移和pTNM分期有关，而与患者年龄及肿瘤大小无关。［结论］ Runx2及Slug可能成为预测乳腺癌恶性程度和评估乳腺癌患者预后的重要指标。 |
| 英文摘要: |
| Abstract：［Objective］ To investigate the expression and clinical significance of Runx2 and Slug in patients with breast cancer. ［Methods］ The expression of Runx2 and Slug was detected in 105 cases of primary breast invasive ductal carcinoma(IDC) and 105 cases of para-tumor breast tissues by immunohistochemistry，and the relationship between expression of Runx2 and Slug with the clinical pathological features of breast cancer was evaluated. ［Results］ The positive expression rates of Runx2 and Slug in IDC were 69.52%（73/105） and 42.86%(45/105) respectively，which were higher than those in para-tumor breast tissues(P<0.05). The expression of Runx2 and Slug both negatively correlated with the expression of ER in IDC(r=-0.302，P<0.01；r=-0.368，P<0.01). Furthermore，Runx2 and Slug expression showed a significant relationship with histopathologic grade，lymph node metastasis and pTNM stage of IDC，but did not correlate with patients’ age and tumor size. ［Conclusion］ Runx2 and Slug may be important factors to evaluate the malignant degree and assess the prognosis in patients with breast cancer. |
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