| 但卫斌,黄小芳,吴大和.60例非小细胞肺癌中IL-21R、MMP-2的表达及意义[J].肿瘤学杂志,2017,23(7):610-614. |
| 60例非小细胞肺癌中IL-21R、MMP-2的表达及意义 |
| Expression and Significance of IL-21R and MMP-2 in 60 Cases with Non-small Cell Lung Cancer |
| 投稿时间：2016-08-24 |
| DOI：10.11735/j.issn.1671-170X.2017.07.B010 |
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| 中文关键词: 非小细胞肺癌 白介素-21受体 基质金属蛋白酶-2 相关性 |
| 英文关键词:non-small cell lung cancer interleukin-21 receptor matrix metalloproteinase-2 correlation |
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| 摘要点击次数: 2074 |
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| 中文摘要: |
| 摘 要：［目的］ 探讨非小细胞肺癌(NSCLC)组织中IL-21R与MMP-2的表达及其在NSCLC增长和转移中的作用。［方法］检测并比较60例非小细胞肺癌组织以及60例正常肺组织中IL-21R、MMP-2的表达，比较其阳性表达率与NSCLC患者恶性生物学行为的关系，并进行相关性及预后分析。［结果］ IL-21R、MMP-2阳性率在NSCLC中的表达显著性高于癌旁正常组织(P<0.05)。IL-21R与肿瘤直径有关，IL-21R和MMP-2的表达与淋巴结转移、组织分化、临床分期均相关(P<0.05)。多因素Logistic回归分析显示，IL-21R和MMP-2高水平表达、淋巴结转移、组织学分化、临床分期是NSCLC患者的独立预后因素。［结论］ NSCLC中IL-21R表达和MMP-2表达与肿瘤恶性生物学行为有关，可作为肺癌预后的客观指标。 |
| 英文摘要: |
| Abstract：［Objective］ To investigate the expression of interleukin-21 receptor IL-21R (IL-21R) and matrixmetalloproteinases-2(MMP-2) in non-small cell lung cancer (NSCLC) and its role in the growth and metastasis of NSCLC. ［Methods］ The expression IL-21R and MMP-2 in 60 cases with NSCLC and 60 cases of normal lung tissue were detected. The relationship between the positive expression of IL-21R and MMP-2 and the biological features of NSCLC patients was compared and the correlation analysis was undertaken.［Results］ The positive rate of IL-21R and MMP-2 in NSCLC were significantly higher than those in adjacent normal tissues，and the expression of IL-21R and MMP-2 showed negative correlation(P<0.05). IL-21R was related to tumor diameter， and the expression of IL-21R and MMP-2 was related to lymph node metastasis，tissue differentiation and clinical stage(P<0.05). Multivariate regression analysis showed that IL-21R and MMP-2 highly expressed. lymph node metastasis，histological differentiation and clinical stage were independent prognostic factors in patients with NSCLC. ［Conclusion］ Expression of IL-21R and MMP-2 in NSCLC are related to the malignant biological behavior of the tumor，which can be used as an objective index for the prognosis of lung cancer. |
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