| 卫美蓉,闻丽芬,李 玙.长链非编码RNA与肿瘤相关性的研究进展[J].肿瘤学杂志,2017,23(6):535-540. |
| 长链非编码RNA与肿瘤相关性的研究进展 |
| Progress on Long Non-coding RNA in Cancer Research |
| 投稿时间：2016-12-13 |
| DOI：10.11735/j.issn.1671-170X.2017.06.B015 |
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| 中文关键词: 长链非编码RNA 肿瘤 生物标志物 |
| 英文关键词:lncRNA tumor biomarker |
| 基金项目: |
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| 中文摘要: |
| 摘 要：长链非编码RNA(long non-coding RNA，lncRNA)是细胞中一类转录本长度大于200nt(核苷酸单位)的非编码RNA分子，其本身并不编码蛋白或很少有编码蛋白质的功能，且在哺乳动物基因组中普遍被转录。起初认为它是转录过程中的副产物，并不具有生物学功能。随着研究的进展，更多新的lncRNA被人们所认识，而且还发现其与物种进化、胚胎发育、物质代谢以及肿瘤发生等都有着密切的联系。近年来研究发现IncRNA在恶性肿瘤中有显著的组织特异性，并且在恶性肿瘤的临床诊断及预后判断中可能发挥重要作用。全文对LncRNAs在肿瘤中的研究进展作一综述。 |
| 英文摘要: |
| Abstract：Longnon coding RNAs(lncRNAs)are defined as transcripts longer than 200 nt with little or no proteincoding capacity that are generally transcribed in the mammalian genome．Initially，they are considered to be a byproduct in the transcription process without biological function.As investigations have progressed，new lncRNAs have been constantly found. And lncRNAs have been found to affect species evolution，embryonic development，metabolism and tumorigenesis. Recent studies suggest that LncRNAs tissue specially expressed in several human cancers，and might play a key role in the diagnosis and prognostic of these malignant neoplasms. This review summarizes the relationship between IncRNA and the occurrence and development of malignancies. |
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