卢 霞,孟晶晶,柏 江.18F-FDG PET/CT在心脏肿瘤诊断的临床应用价值[J].肿瘤学杂志,2017,23(6):474-478.
18F-FDG PET/CT在心脏肿瘤诊断的临床应用价值
Clinical Application of 18F-FDG PET/CT in Diagnosis of Cardiac Neoplasm
投稿时间:2017-03-18  
DOI:10.11735/j.issn.1671-170X.2017.06.B004
中文关键词:  心脏肿瘤  18F-FDG PET/CT  鉴别诊断
英文关键词:heart neoplasms  18F-FDG PET/CT  noninvasive differential diagnosis
基金项目:国家自然科学基金(81641072);北京市医院管理局“青苗”计划(QML20150605);北京市优秀人才(2015000021469G197)
作者单位
卢 霞 首都医科大学附属北京安贞医院 
孟晶晶 首都医科大学附属北京安贞医院 
柏 江 首都医科大学附属北京安贞医院 
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中文摘要:
      摘 要:[目的] 评价18F-FDG PET/CT在心脏肿瘤诊断中的临床应用价值。[方法] 回顾性分析自2014年10月至2017年3月在首都医科大学附属北京安贞医院行18F-FDG PET/CT全身显像的心脏肿瘤患者共27例,患者最终诊断以手术病理结果或随访结果为依据。18F-FDG PET/CT影像心脏占位病变可见明显异常FDG浓聚灶,SUVmax≥5.7判断为恶性病变可能大,并与最终诊断结果进行比较,分析18F-FDG PET/CT在心脏占位性病变良恶性的鉴别能力。采用两样本t检验分析数据。[结果] 27例心脏肿瘤患者中,恶性11例,良性占位16例。18F-FDG PET/CT显像,恶性占位(n=11)平均SUVmax 9.03±4.5(2.0~15.9)明显高于良性心脏占位性病变(n=16)平均SUVmax 3.25±2.51(0.6~10.2),差异有统计学意义(t=4.25,P<0.001)。将SUV≥5.7作为恶性诊断的阈值,18F-FDG PET/CT诊断心脏恶性肿瘤的灵敏度81.8% (9/11),特异性93.8%(15/16),准确率88.9%(24/27)。[结论] 全身18F-FDG PET/CT检查对心脏肿瘤,特别是原发性心脏肿瘤良恶性诊断有重要的临床价值。
英文摘要:
      Abstract:[Objective] To evaluate the clinical value of 18F-FDG PET/CT in the diagnosis of cardiac neoplasm.[Methods] From October 2014 to March 2017,a total of 27 patients diagnosed with cardiac neoplasm underwent whole body 18F-FDG PET/CT imaging were respectively analysised. 18F-FDG PET/CT diagnosis was confirmed by either histopathology or the follow-up outcome. Cardiac space-occupying lesions shows increased FDG uptake in the imaging of PET/CT and diagnosed malignance lesions when SUVmax≥5.7. Then compared with histopathology or the follow-up outcome to evaluate the clinical application of 18F-FDG PET/CT imaging in the diagnosis of cardiac neoplasm. Two-sample t test was used for data analysis. [Results] Among 27 cases of cardiac space-occupying lesions,11 cases were malignant tumors,16 cases were benign tumors. The average SUVmax of malignant tumors (n=11) was 9.03±4.5,which was significantly higher than that of benign tumors(n=16,3.25±2.51)(t=4.25,P<0.001). With a cut-off SUVmax≥ 5.7,18F-FDG PET/CT could be used to diagnose cardiac neoplasm with a sensitivity of 81.8% (9/11),specificity of 93.8%(15/16),and accuracy of 88.9%(24/27). [Conclusion] The whole body scan of 18F-FDG PET/CT can aid the noninvasive diagnosis of cardiac malignant tumors from benign lesions.
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