| 赵 靖,王荣福.18F-FDG PET/CT在急性白血病诊治中的临床应用进展[J].肿瘤学杂志,2017,23(6):464-469. |
| 18F-FDG PET/CT在急性白血病诊治中的临床应用进展 |
| The Clinical Advances of 18F-FDG PET/CT in the Management of Patients with Acute Leukemia |
| 投稿时间：2017-02-14 |
| DOI：10.11735/j.issn.1671-170X.2017.06.B002 |
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| 中文关键词: 急性白血病 18F-FDG PET/CT 髓外浸润 |
| 英文关键词:acute leukemia 18F-FDG PET/CT extramedullary infiltration |
| 基金项目:国家重大科学仪器设备开发专项（2011YQ03011409）；十二五国家支撑项目基金（2014BAA03B03） |
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| 中文摘要: |
| 摘 要：急性白血病治疗后首次缓解率很高，但其复发率及死亡率也不低，尤其髓外浸润灶的发现及诊断，仍然是临床上的一项重大挑战。目前国内外关于18F-FDGPET/CT应用于白血病诊治尚未系统研究，但18F-FDG PET/CT能在保持PET的高灵敏度探测的同时，通过多层螺旋CT的高分辨率，显示病变的精细结构特征，提高病变的检测能力和准确率。特别是在白血病髓外浸润灶的检出和复发监测方面，PET/CT展现出显著优势。全文旨在对近年国内外18F-FDG PET/CT在急性白血病诊断、分期、再分期、治疗反应评估和监测复发等诊治过程中的临床应用进展进行综述。 |
| 英文摘要: |
| Abstract：High rates of relapse and mortality of acute leukemia persist despite high rates of initial complete remission. Extramedullary disease，especially，remains a significant challenge to cure acute leukemia patients. Although the value of PET/CT has not been systematically assessed and limited data has been reported on its utility in patients with acute leukemia，18F-FDG PET/CT can maintain the high sensitivity of PET while detecting the fine structure characteristics of the lesions through the high resolution of multi-slice helical CT，which can improve the detection ability and accuracy for the lesions. Especially in the detection and monitoring of relapse of leukemic extramedullary infiltrates，PET/CT shows significant advantages. This article aims to summarize the progress both in China and abroad regarding the clinical application of 18F-FDG PET/CT in diagnosis，initial staging，restaging，evaluating treatment response and monitoring recurrence of acute leukemia. |
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