| 汪伟民,蔡炜龙,潘 杰.ATDC在肝癌中表达及临床意义[J].肿瘤学杂志,2017,23(5):409-412. |
| ATDC在肝癌中表达及临床意义 |
| Expression of ATDC in Hepatic Carcinoma and its Clinical Significance |
| 投稿时间：2016-06-18 |
| DOI：10.11735/j.issn.1671-170X.2017.05.B010 |
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| 中文关键词: ATDC 免疫组织化学 肝癌 恶性进展 |
| 英文关键词:ATDC immunohistochemistry HCC malignant progression |
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| 中文摘要: |
| 摘 要：［目的］ 研究ATDC在肝癌中表达及临床意义。［方法］ 采用免疫组化方法检测56对肝癌及癌旁组织中ATDC表达情况，分析其表达与临床资料及预后的关系。 ［结果］ ATDC在肝癌组织中表达显著性高于癌旁组织（P<0.05）；ATDC高表达与患者TNM分期（P=0.001）及转移（P=0.01）显著性相关；ATDC高表达患者术后5年生存率与生存时间均显著性低于低表达者（P=0.04）。 ［结论］ 肝癌中ATDC高表达与高恶性度及预后不良相关，可作为肝癌诊断、治疗及预后判定的重要标志物。 |
| 英文摘要: |
| Abstract：［Objective］ To investigate the expression of ataxia-telangiectasia group D complementing gene(ATDC) in hepatocellular carcinoma(HCC) and its clinicopathological significance. ［Methods］ The expression of ATDC was detected by immunohistochemistry in cancer tissue and corresponding paracancerous tissue of 56 patients with HCC. The correlation of ATDC expression with clinicopathological characteristics and prognosis of HCC patients was analyzed. ［Results］ The ATDC expression in HCC was significantly higher than that in corresponding paracancerous tissues. The ATDC expression was significantly correlated with TNM stage(P=0.001) and tumor metastasis(P=0.01). Patients with higher ATDC expressions had poorer 5-year survival after surgery and shorter survival time than those with lower ATDC expression(P=0.04). ［Conclusion］ Higher ATDC expression in HCC is associated with advanced malignancy and poor prognosis，indicating that ATDC might be used as a biomarker for diagnosis，treatment and prognosis for HCC patients. |
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