郭雪芬,王若雨,李贺明.外周血血小板/淋巴细胞比值与胆道系统肿瘤预后的相关性[J].肿瘤学杂志,2017,23(4):300-304.
外周血血小板/淋巴细胞比值与胆道系统肿瘤预后的相关性
Relationship of Peripheral Blood Platelet to Lymphocyte Ratio with Clinicopathological Features and Prognosis of Biliary Tract Cancer
投稿时间:2016-11-02  
DOI:10.11735/j.issn.1671-170X.2017.04.B010
中文关键词:  血小板/淋巴细胞比值  胆道系统肿瘤  预后
英文关键词:biliary tract cancer  platelet-to-lymphocyte ratio  prognosis
基金项目:国家自然科学基金资助项目(81502124)
作者单位
郭雪芬 大连大学附属中山医院 
王若雨 大连大学附属中山医院 
李贺明 大连大学附属中山医院 
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中文摘要:
      摘 要:[目的] 探讨外周血血小板/淋巴细胞比值(platelet to lymphocyte ratio,PLR)与胆道系统恶性肿瘤临床病理特征的相关性及其对预后的影响。[方法] 系统回顾126例胆道系统肿瘤患者的临床病理资料,PLR分组根据格拉斯哥预后评分(The Glasgow Prognostic Score,GPS )中对PLR定义的界值,将PLR分为低PLR组(PLR<150)和高PLR组(PLR≥150)。分析PLR水平与胆道系统肿瘤患者临床病理因素的相关性;通过单因素、多因素分析探讨PLR与胆道系统肿瘤预后的相关性。[结果]高PLR组胆道系统肿瘤患者的总生存期(overall survival,OS)与无进展生存期(progression-free survival,PFS)均低于低PLR组,但差异均无统计学意义(P>0.05);单因素分析结果显示纤维蛋白原(Fibrinogen,FG)与胆道系统肿瘤患者的OS和PFS的均有相关性(P<0.05);年龄、PS评分及中性粒细胞与淋巴细胞比值( neutrophil to lymphocyte ratio,NLR)与PFS有相关性(P<0.05);肿瘤部位、TNM分期与OS有相关性(P<0.05)。多因素分析结果表明年龄、FG是胆道系统肿瘤预后的独立危险因素。分层分析结果显示,不同年龄分组中,PLR与OS和PFS均无相关性(P>0.05)。[结论]目前样本分析结果表明PLR不能作为胆道系统肿瘤预后的一个指标,但仍需继续扩大样本量进一步证实。
英文摘要:
      Abstract:[Objective] To investigate the association of peripheral platelet to lymphocyte ratio(PLR) with clinicopathological features and prognosis of biliary tract cancer.[Methods] Data of 126 patients with biliary tract cancer were retrospectively evaluated. According to the definition of PLR in Glasgow Prognostic Score(GPS),patients were divided into low PLR group(PLR <150) and high PLR group(PLR≥150). The correlation of PLR with clinicopathological features and prognosis of biliary cancer was analyzed by using univariate and multivariate analyses. [Results] There were no significant differences in overall survival(OS) and progression-free survival(PFS) between high PLR group and low PLR group(P>0.05). Univariate analysis showed that fibrinogen(FG) was correlated with OS and PFS in biliary tract cancer patients(P<0.05);the age,PS score and neutrophil-to-lymphocyte ratio(NLR) were statistically correlated with PFS(P<0.05);the tumor site,TNM stage were statistically correlated with OS(P<0.05). Multivariate analysis showed that age and FG were independent risk factors for biliary tract cancer prognosis.[Conclusion] The present study indicates that PLR may not serve as a predicator for prognosis of biliary tract cancer.
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