| 邸丽娟,王荣福,张建华.18F-FDG PET/CT半定量参数 SUVmax对肾透明细胞癌分级分期的预测价值[J].肿瘤学杂志,2017,23(4):295-299. |
| 18F-FDG PET/CT半定量参数 SUVmax对肾透明细胞癌分级分期的预测价值 |
| Correlation of SUVmax of 18F-FDG PET/CT Scan with Nuclear Grade and Pathological Stage of Renal Clear Cell Carcinoma |
| 投稿时间：2017-02-16 |
| DOI：10.11735/j.issn.1671-170X.2017.04.B009 |
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| 中文关键词: 肾透明细胞癌 标准摄取比值 正电子发射型计算机断层扫描 分级 分期 |
| 英文关键词:renal clear cell carcinoma value of standardized uptake positron emission tomography/computed tomography grade stage |
| 基金项目:国家重大科学仪器设备开发专项（2011YQ03011409）；国家“十二五”支撑项目基金（2014BAA03B03） |
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| 中文摘要: |
| 摘 要：［目的］分析18F-FDG PET/CT葡萄糖代谢活性参数最大标准摄取比值（maximum of standardized uptake value，SUVmax）对肾透明细胞癌分级、分期的预测价值。［方法］ 回顾性分析行18F-FDG PET/CT检查的51例肾透明细胞癌患者（Fuhrman分级G1级16例、G2级23例、G3级和G4级12例；pT分期为1和2期29例，3和4期13例），所有患者经手术或穿刺病理证实为透明细胞癌，根据18F-FDG PET/CT图像，测定葡萄糖代谢参数SUVmax和肿瘤直径。分析不同Fuhrman分级、pT分期病灶的SUVmax差异情况，以及肿瘤的SUVmax与其大小的相关性。［结果］ G1级、G2级、G3级与G4级三组病灶SUVmax中位数分别为2.15（1.83～2.83）、3.60（2.40～6.30）、10.05（7.73～14.08），差异有统计学意义（χ2=26.11，P<0.001）。以6.65为界值，SUVmax≥6.65时，鉴别高级别肾透明细胞癌（G3、G4）的灵敏度和特异性分别为91.7%、84.7%，曲线下面积为0.938（P<0.001）。pT分期早期（1、2期）与晚期（3、4期）组SUVmax中位数分别为2.30（1.80～2.80）、6.00（3.90～11.10），差异有统计学意义（Z=-3.98，P<0.001）。以3.10为界值，SUVmax≥3.10时，鉴别晚期肾透明细胞癌（pT3期、pT4期）的灵敏度和特异性分别是 94.7%、87.0 %，曲线下面积为 0.860（P<0.001）。病灶的SUVmax（1.5～17.7）与肿瘤的直径（0.70～17.70cm）有一定程度的正相关（r=0.62，P<0.001）。［结论］ 肾透明细胞癌的SUVmax与肿瘤Fuhrman分级、pT分期有一定关系，利用SUVmax，18F-FDG PET/CT可以预测肿瘤的分级和分期。 |
| 英文摘要: |
| Abstract：［Objective］ To evaluate the correlation of maximum standardized uptake value(SUVmax) in 18F-FDG PET/CT scan with the nuclear grade and pathological stage of renal clear cell carcinoma(ccRCC). ［Methods］ Fifty one patients with nephrectomy or tissue biopsy-proved ccRCC(including 16 G1，23 G2，12 G3 and G4；29 early stage with pT1 and pT2，13 late-stage with pT3 and pT4) underwent 18F-FDG PET/CT examination. The SUVmax and tumor diameter were evaluated by PET/CT. The correlations of SUVmax with tumor diameter and pathologic parameters Fuhrman grades，pT stages were analyzed. ［Results］ The median SUVmax of G1(n=16)，G2(n=12)，G3 and G4(n=23) tumor was 2.15(1.83～2.83)，3.60(2.40～6.30) and 10.05(7.73～14.08)，respectively(χ2=26.11，P<0.001). With the cutoff value of 6.65，the sensitivity and specificity of SUVmax in differentiating high-grade(G3 and G4) from low-grade(G1 and G2) ccRCC were 91.7% and 84.7%(AUC was 0.938，P<0.001)，respectivley. The median SUVmax of early-stage and late-stage tumor was 2.30(1.80～2.80) and 6.00(3.90～11.10)，respectively（Z=-3.98，P<0.001）. With the cutoff value of 3.10，the sensitivity and specificity of SUVmax in differentiating late-stage from early-stage ccRCC were 94.7% and 87.0%，respectively(AUC was 0.860，P<0.001). The spearman correlation?coefficient between tumor diameter and SUVmax was 0.62(P<0.001). ［Conclusion］ Higher FDG uptake suggests a high-grade and late pT stage ccRCC. Using SUVmax，18F-FDG PET/CT may indicate pathological grade and stage of ccRCC. |
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