李营歌,宋启斌,姚 颐.癌相关成纤维细胞在肿瘤疗效预测和预后判断中的应用价值[J].肿瘤学杂志,2017,23(3):233-237. |
癌相关成纤维细胞在肿瘤疗效预测和预后判断中的应用价值 |
Cancer Associated Fibroblast and its Application in Therapeutic Effect Evaluation and Prognosis in Malignant Tumor |
投稿时间:2016-11-08 |
DOI:10.11735/j.issn.1671-170X.2017.03.B015 |
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中文关键词: 癌相关成纤维细胞 标记物 基因 肿瘤间质 预测 预后 |
英文关键词:cancer associated fibroblast biomarker gene tumor stroma prediction prognosis |
基金项目:基金项目:国家自然科学基金(81372407) |
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中文摘要: |
摘 要:癌相关成纤维细胞(CAF)是肿瘤微环境中重要的细胞成分,不仅为肿瘤的发生、发展提供条件,还帮助癌细胞侵袭、转移、形成耐药性和产生放射抗性等,因此有人提出CAF可作为抗肿瘤治疗的新靶标。研究发现,CAF及其相关蛋白和基因检测指标,还可作为恶性肿瘤药物疗效预测以及患者预后判断的重要参考。全文就癌相关成纤维细胞在肿瘤疗效预测和预后判断中的应用价值作一综述。 |
英文摘要: |
Abstract:Cancer associated fibroblast(CAF),as an important cell component in tumor microenvironment,is involved in cancer generation,progression,invasion and metastasis of malignant tumors,it also enhance the resistance of cancer cells to the chemotherapy and radiotherapy. Therefore,CAF might be used as a new target in the tumor therapy. Recent studies show that CAF and CAF-related proteins and genes can be used as biomarkers for therapeutic effect evaluation and prognosis of malignant tumor. In this article we discuss cancer-related CAF and its potential application in clinical management of malignant tumor. |
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