| 范稀文,王高仁,赵 森.放疗致颈动脉损伤的研究进展[J].肿瘤学杂志,2017,23(3):221-226. |
| 放疗致颈动脉损伤的研究进展 |
| Research Progress on Carotid Injury Induced by Radiation Therapy |
| 投稿时间：2016-04-16 |
| DOI：10.11735/j.issn.1671-170X.2017.03.B013 |
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| 中文关键词: 放射疗法 颈动脉损伤 发病机制 危险因素 诊断 |
| 英文关键词:radiotherapy carotid injury pathogenesis risk factors diagnosis |
| 基金项目: |
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| 摘要点击次数: 1818 |
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| 中文摘要: |
| 摘 要：近年来随着放疗技术的提高及多学科综合治疗的运用，头颈部恶性肿瘤患者的生存期明显延长。颈部放疗后引起的血管损伤以及后期发展形成的颈动脉狭窄（carotid artery stenosis，CAS）越来越引起更多的关注。许多研究表明放射线可促使血管内皮活化，并在氧化损伤机制和炎性反应的参与下引起血管内皮损伤，促进颈动脉内膜中层厚度（carotid intima-media thickness，CIMT）增加，导致颈动脉狭窄，从而增加发生脑血管事件的风险，如短暂性脑缺血发作和脑卒中。文章就有关颈部放疗后诱导颈动脉损伤的发生率、发病机制、危险因素、临床特点、诊断及治疗方法、未来研究领域进行综述。 |
| 英文摘要: |
| Abstract：With the improvement of radiotherapy technology and comprehensive treatment，the survival of patients with head and neck malignancies has gained remarkable progress. On the other hand，vascular injury and subsequent carotid artery stenosis(CAS) following radiotherapy have received increasing attention. Many studies have shown that radiation can induce endothelial activation and vascular injury with the participation of oxidative damage and inflammatory response，which result in the increase in carotid intima-media thickness(CIMT) and CAS，consequently lead to a higher risk of cerebrovascular events such as transient ischemic attack and stroke. This article reviews the incidence，pathogenesis，risk factors and characteristics of radiation-induced carotid artery injury; and its treatment，prevention and suggestions for future studies are also discussed. |
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