| 郭 茜,齐秀恒,武振明.70岁以上老年结直肠癌患者273例临床病理及预后分析[J].肿瘤学杂志,2017,23(3):214-217. |
| 70岁以上老年结直肠癌患者273例临床病理及预后分析 |
| Clinicopathology and Prognosis of Elderly Patients with Colo-rectal Cancer：An Analysis of 273 Cases |
| 投稿时间：2016-11-04 |
| DOI：10.11735/j.issn.1671-170X.2017.03.B011 |
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| 中文关键词: 结直肠肿瘤 老年人 临床病理学 |
| 英文关键词:colorectal neoplasms elderly clinicopathology |
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| 中文摘要: |
| 摘 要：［目的］ 探讨70岁以上老年结直肠癌患者临床特点及预后。［方法］ 回顾性分析 273 例年龄≥70岁的老年结直肠癌患者的临床资料。［结果］ 70岁以上的新发老年结直肠癌患者占同期住院结直肠癌患者的29.4%（273/927），伴随有基础疾病者205例（75.1%），癌胚抗原（CEA）异常92例（33.7%），D-二聚体异常129例（47.3%），血小板增高89例（32.6%）。病理类型以中分化腺癌居多，116例（42.5%）；病理分期以Ⅲ、Ⅳ期为主，Ⅲ期109例（39.9%），Ⅳ期130例（47.6%）；远处转移中单发转移78例（60.0%），多发转移52例（40.0%）；肝转移92例（70.8%），肝外转移38例（29.2%）。接受手术治疗190例（69.6%），接受化疗171例（62.6%），接受放疗85例（31.1%），仅行姑息支持治疗68例（24.9%）。患者中位生存时间30个月，1年生存率为85.7%（234/273），3年生存率为60.8%（166/273），5年生存率为30.8%（84/273）。69例（36.5%）死于肿瘤进展，98例（51.9%）死于其他基础疾病。［结论］ 老年结直肠癌患者，尤其70岁以上患者，伴随的基础疾病、合并症增多，对于这部分患者既要进行个体化抗肿瘤治疗，又要兼顾伴随疾病的管理。规范化个体化治疗能使患者生存期延长。 |
| 英文摘要: |
| Abstract：［Objective］ To analyze the clinicopathologic characteristics and prognosis of elderly patients with colorectal cancer. ［Methods］ Total 927 patients with colorectal cancer were admitted in our hospital during January 2008 to October 2011，among whom 273 were aged 70 or above(29.4%). The clinical data of 273 elderly patients were analyzed retrospectively. ［Results］ Among 273 elderly patients，205 cases(75.1%) were complicated with chronic diseases including hypertension，cardiac disease，diabetes or others；92 cases(33.7%) presented abnormal serum carcinoembryonic antigen(CEA)，129 cases(47.3%) had abnormal D-dimeride，89 cases(32.6%) had thrombocytosis. The highly differentiated adenocarcinoma was the most common pathological type(116 cases，42.5%). There were 109 cases with stage Ⅲ(39.9%) and 130 cases with stage Ⅳ(47.6%)；there were 78 cases(60.0%) with single metastasis，52 cases(40.0%) with multiple metastases；92 cases(70.8%) with liver metastasis and 38 cases(29.2%) with extra-hepatic metastasis. 190 cases(69.6%) received surgical，171 cases(62.6%) received chemotherapy and 85 cases(31.1%) received radiotherapy. The1-，3-，5-year survival rates were 85.7%（234/273），60.8%（166/273） and 30.8%（84/273）with median survival time of 30 months. Sixty nine cases（36.5%）died from tumor progression and 98 cases（51.9%）died from other causes. ［Conclusion］ Most elderly colorectal cancer patients are complicated with chronic diseases. For these patients，individualized antitumor treatment and management of accompanied diseases are necessary，which would prolong survival of the patients. |
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