郭 茜,齐秀恒,武振明.70岁以上老年结直肠癌患者273例临床病理及预后分析[J].肿瘤学杂志,2017,23(3):214-217. |
70岁以上老年结直肠癌患者273例临床病理及预后分析 |
Clinicopathology and Prognosis of Elderly Patients with Colo-rectal Cancer:An Analysis of 273 Cases |
投稿时间:2016-11-04 |
DOI:10.11735/j.issn.1671-170X.2017.03.B011 |
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中文关键词: 结直肠肿瘤 老年人 临床病理学 |
英文关键词:colorectal neoplasms elderly clinicopathology |
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中文摘要: |
摘 要:[目的] 探讨70岁以上老年结直肠癌患者临床特点及预后。[方法] 回顾性分析 273 例年龄≥70岁的老年结直肠癌患者的临床资料。[结果] 70岁以上的新发老年结直肠癌患者占同期住院结直肠癌患者的29.4%(273/927),伴随有基础疾病者205例(75.1%),癌胚抗原(CEA)异常92例(33.7%),D-二聚体异常129例(47.3%),血小板增高89例(32.6%)。病理类型以中分化腺癌居多,116例(42.5%);病理分期以Ⅲ、Ⅳ期为主,Ⅲ期109例(39.9%),Ⅳ期130例(47.6%);远处转移中单发转移78例(60.0%),多发转移52例(40.0%);肝转移92例(70.8%),肝外转移38例(29.2%)。接受手术治疗190例(69.6%),接受化疗171例(62.6%),接受放疗85例(31.1%),仅行姑息支持治疗68例(24.9%)。患者中位生存时间30个月,1年生存率为85.7%(234/273),3年生存率为60.8%(166/273),5年生存率为30.8%(84/273)。69例(36.5%)死于肿瘤进展,98例(51.9%)死于其他基础疾病。[结论] 老年结直肠癌患者,尤其70岁以上患者,伴随的基础疾病、合并症增多,对于这部分患者既要进行个体化抗肿瘤治疗,又要兼顾伴随疾病的管理。规范化个体化治疗能使患者生存期延长。 |
英文摘要: |
Abstract:[Objective] To analyze the clinicopathologic characteristics and prognosis of elderly patients with colorectal cancer. [Methods] Total 927 patients with colorectal cancer were admitted in our hospital during January 2008 to October 2011,among whom 273 were aged 70 or above(29.4%). The clinical data of 273 elderly patients were analyzed retrospectively. [Results] Among 273 elderly patients,205 cases(75.1%) were complicated with chronic diseases including hypertension,cardiac disease,diabetes or others;92 cases(33.7%) presented abnormal serum carcinoembryonic antigen(CEA),129 cases(47.3%) had abnormal D-dimeride,89 cases(32.6%) had thrombocytosis. The highly differentiated adenocarcinoma was the most common pathological type(116 cases,42.5%). There were 109 cases with stage Ⅲ(39.9%) and 130 cases with stage Ⅳ(47.6%);there were 78 cases(60.0%) with single metastasis,52 cases(40.0%) with multiple metastases;92 cases(70.8%) with liver metastasis and 38 cases(29.2%) with extra-hepatic metastasis. 190 cases(69.6%) received surgical,171 cases(62.6%) received chemotherapy and 85 cases(31.1%) received radiotherapy. The1-,3-,5-year survival rates were 85.7%(234/273),60.8%(166/273) and 30.8%(84/273)with median survival time of 30 months. Sixty nine cases(36.5%)died from tumor progression and 98 cases(51.9%)died from other causes. [Conclusion] Most elderly colorectal cancer patients are complicated with chronic diseases. For these patients,individualized antitumor treatment and management of accompanied diseases are necessary,which would prolong survival of the patients. |
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