| 邓 敏,解瑞飞,王 惠.FGFR-1、CyclinD1在胃癌中的表达及其意义[J].肿瘤学杂志,2017,23(3):205-209. |
| FGFR-1、CyclinD1在胃癌中的表达及其意义 |
| Expression of FGFR-1 and CyclinD1 in Gastric Cancer and its Clinical Significance |
| 投稿时间：2016-10-26 |
| DOI：10.11735/j.issn.1671-170X.2017.03.B009 |
|
 |
| 中文关键词: 成纤维生长因子受体-1 细胞周期蛋白D1 胃肿瘤 免疫组化 酪氨酸激酶 |
| 英文关键词:FGFR-1 CyclinD1 gastric neoplasms immunohistochemistry tyrosine kinase |
| 基金项目:浙江省省级公益性技术应用研究计划项目（2015C33268）；富阳市科技发展计划项目（2011SF004） |
|
| 摘要点击次数: 1734 |
| 全文下载次数: 576 |
| 中文摘要: |
| 摘 要：［目的］ 探讨成纤维生长因子受体-1（FGFR-1）及细胞周期蛋白D1（CyclinD1）在胃癌组织中的表达及其临床意义。［方法］ 应用免疫组织化学S-P法检测70例胃癌（24例腺癌，21例黏液腺癌，25例印戒细胞癌）组织中FGFR-1、CyclinD1蛋白水平的表达。［结果］ 胃癌中FGFR-1蛋白的阳性率为61.4%（43/70），明显高于癌旁组织的37.5%（15/40）（P<0.05）；FGFR-1在浸润深度超过肌层2/3病例中阳性率为79.5%（31/39），浸润深度未达到肌层2/3病例中阳性率为38.7%（12/31）（P<0.05）；伴区域淋巴结转移病例阳性率为69.4%（34/49），无区域淋巴结转移病例阳性率为42.9%（9/21）（P<0.05）。胃癌中CyclinD1蛋白的阳性率为64.3%（45/70），明显高于癌旁组织的25.0%（10/40）（P<0.05）；CyclinD1在浸润深度超过肌层2/3病例中阳性率为79.5%（31/39），浸润深度未达到肌层2/3病例中阳性率为45.2%（14/31）（P<0.05）；伴区域淋巴结转移病例阳性率为73.5%（36/49），无区域淋巴结转移病例阳性率为42.9%（9/21）（P<0.05）。［结论］ FGFR-1在胃癌中表达上调，与胃癌的浸润和转移密切相关，其可能通过上调CyclinD1的表达而发挥作用。 |
| 英文摘要: |
| Abstract：［Objective］ To investigate the expression of FGFR-1 and CyclinD1 in gastric cancer and its clinical significance. ［Methods］ The expression of FGFR-1 and CyclinD1 protein in 70 cases of gastric cancer，including 24 cases of adenocarcinoma，21 cases of mucinous adenocarcinoma and 25 cases of ring cell carcinoma were examined by S-P immunohistochemistry. ［Results］ The overall positive rate of FGFR-1 in gastric cancer was 61.4%(43/70) ，which was significantly higher than that in adjacent gastric tissues(P<0.05). The positive rate of FGFR-1 in gastric cancer infiltrating over 2/3 muscular layer and less 2/3 muscular layer was 79.5%(31/39) and 38.7%(12/31)，respectively(P<0.05). The positive rate of FGFR-1 in gastric cancer with or without regional lymph nodes metastasis was 69.4%(34/49) and 42.9%(9/21)，respectively(P<0.05). The overall positive rate of cyclinD1 in gastric cancer tissue was 64.3%(45/70)，which was significantly higher than that in adjacent tissues(P<0.05).The positive rate of CyclinD1 in gastric cancer infiltrating over 2/3 muscular layer and less 2/3 muscular layer was 79.5%(31/39) and 45.2%(14/31)，respectively(P<0.05). The positive rate of CyclinD1 in the patients with or without regional lymph nodes metastasis was 73.5%(36/49) and 42.9%(9/21)，respectively(P<0.05). ［Conclusion］ The FGFR-1 is over expressed in gastric cancer，and closely related to gastric parietal penetration and regional lymph nodes metastasis. The over-expression of FGFR may be associated with up-regulating the expression of CyclinD1. |
|
在线阅读
查看全文 查看/发表评论 下载PDF阅读器 |