| 周昱川,王雪阳,陈青立.Hippo信号通路中TAZ、P-TAZ、Mst1/2与[J].肿瘤学杂志,2017,23(3):199-204. |
| Hippo信号通路中TAZ、P-TAZ、Mst1/2与 |
| Expression and Significance of Hippo Signaling Pathway-related Proteins in Oral Squamous Cell Carcinoma |
| 投稿时间：2016-09-19 |
| DOI：10.11735/j.issn.1671-170X.2017.03.B008 |
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| 中文关键词: 口腔鳞状细胞癌 Hippo信号通路 TAZ蛋白 Mst1/2蛋白 |
| 英文关键词:oral squamous cell carcinoma Hippo pathway TAZ protein Mst1/2 protein |
| 基金项目:新疆重大疾病医学重点实验室开放课题（SKLIB-XJMDR-2014-7） |
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| 中文摘要: |
| 摘 要：［目的］ 检测Hippo信号通路相关蛋白TAZ、磷酸化TAZ、Mst1/2、磷酸化Mst1/2在口腔鳞状细胞癌组织中的表达，探讨其对口腔鳞状细胞癌术后肿瘤复发的影响。［方法］ 收集51例口腔鳞癌患者临床病理资料及癌组织标本，用免疫组化法检测口腔鳞癌组织中的TAZ蛋白和P-TAZ蛋白、Mst1/2蛋白和P- Mst1/2蛋白的表达情况，样本率的比较采用χ2检验，对可能影响口腔鳞癌治疗后复发的因素采用Cox比例风险回归分析，绘制TAZ、Mst1/2蛋白的表达情况与口腔鳞癌治疗后的生存曲线。TAZ与Mst1/2相关性研究采用Spearman秩相关分析。［结果］ TAZ在口腔鳞癌组织中阳性表达主要位于细胞核与细胞质中，P-TAZ、Mst1/2、P-Mst1/2阳性表达位于细胞质中。TAZ阳性表达与肿瘤大小、肿瘤组织分化程度、淋巴结有无转移有关（χ2分别为4.488，5.888，4.638，P＜0.05）；Mst1/2阳性表达与肿瘤的大小、肿瘤组织分化程度有关（χ2分别为4.961，10.232，P＜0.05）。肿瘤的大小是影响口腔鳞癌患者术后复发的危险因素（P＜0.05）。TAZ与Mst1/2表达呈负相关（r=-0.480，P＜0.05）。［结论］ Hippo信号通路参与口腔鳞癌的发生、发展。TAZ、P-TAZ、Mst1/2、P- Mst1/2蛋白与口腔鳞癌的预后情况相关。 |
| 英文摘要: |
| Abstract：［Objective］ To investigate the expression of Hippo pathway signaling pathway-related proteins in oral squamous cell carcinoma (OSCC) and their clinical significance. ［Methods］ Fifty one patients with OSCC were enrolled in this study. The expressions of Hippo signaling related proteins TAZ，phosphorylated TAZ (P-TAZ)，Mst1/2 and phosphorylated Mst1/2 (P-Mst1/2) in cancer tissue were detected by immunohistochemical method. Factors influencing the postoperative survival were analyzed using the Cox regression model. The relationship between TAZ protein and Mst1/2 protein was analyzed using Spearman’s correlation coefficient. ［Results］ Positive staining of TAZ was observed in the nucleus and cytoplasm of cancer cells，and the positive straining of p-TAZ，Mst1/2 and p-Mst1/2 was observed in the cytoplasm. The positive expression of TAZ was correlated with tumor diameter，degree of differentiation and lymph node metastasis(χ2=4.488， 5.888，4.638，P＜0.05); the expression of Mst1/2 was correlated with tumor diameter，degree of differentiation (χ2=4.961，10.232，P＜0.05). Univariate analysis showed that tumor diameter was an independent risk factor for postoperative recurrence(P <0.05). The expression of TAZ protein was negatively correlated with Mst1/2 protein(r=-0.480，P<0.05). ［Conclusion］ Hippo pathway may be involved in the occurrence and development of oral squamous cell carcinoma. |
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