| 尼 杰.雄激素受体在Her-2过表达型乳腺癌中的意义[J].肿瘤学杂志,2017,23(3):189-193. |
| 雄激素受体在Her-2过表达型乳腺癌中的意义 |
| Clinical Significance of Androgen Receptor in Breast Cancer Patients with Human Epidermal Growth Factor Receptor-2 Overexpression |
| 投稿时间：2016-11-01 |
| DOI：10.11735/j.issn.1671-170X.2017.03.B006 |
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| 中文关键词: 乳腺肿瘤 雄激素受体 Her-2过表达型乳腺癌 |
| 英文关键词:breast neoplasms androgen receptor human epidermal growth factor receptor-2 overexpression breast cancer |
| 基金项目:邢台市科技支撑计划项目（2015ZC191） |
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| 中文摘要: |
| 摘 要：［目的］ 探讨雄激素受体（androgen receptor，AR）在人表皮生长因子受体-2（human epidermal growth factor receptor-2，Her-2）过表达型乳腺癌中的临床意义。［方法］ 用免疫组化方法检测有完整临床及随访资料的102例Her-2过表达型乳腺癌中AR表达，并分析其与临床病理特征及5年无疾病进展时间（disease-free survinal，DFS)的相关性。［结果］ AR在Her-2过表达型乳腺癌阳性率为75.5%（77/102）；淋巴结阴性组AR表达率为84.91%（45/53），明显高于淋巴结阳性组的65.31%（32/49）(χ2=5.286，P=0.021)；Ki-67阴性组AR表达率（89.47%，34/38）明显高于Ki-67阳性组的67.19%（43/64）(χ2=6.400，P=0.011）。生存分析显示，AR阳性组5年无瘤生存率为71.7%，明显低于AR阴性组的89.8%(χ2=5.736，P=0.017）。Cox回归分析显示，AR是影响Her-2过表达型乳腺癌5年DFS的独立预后因素（RR=3.961，95%CI：1.008~15.574）。［结论］ AR在Her-2过表达型乳腺癌中的表达率高，AR阳性患者预后较差，AR可能成为Her-2过表达型乳腺癌新的治疗靶点。 |
| 英文摘要: |
| Abstract：［Objective］ To investigate the clinical significance of androgen receptor(AR) in breast cancer with Her-2 overexprssion. ［Methods］ The expression of AR was detected by immunohistochemical staining in 102 patients with Her-2 over-expression breast cancer. The relationship between AR expression with clinicopathological characteristics and disease-free survival (DFS) was analyzed. ［Results］ The positive rate of AR expression was 75.5%（77/102）. The AR expression in patients with negative lymph nodes was 84.91% (45/53)，which was significantly higher than that with positive lymph nodes (65.31%，32/49)(χ2=5.286，P=0.021). The AR expression in patient with negative Ki-67 was 89.47%(34/38)，which was significantly higher than that with positive Ki-67 (67.19%，43/64) (χ2=6.400，P=0.011）. The survival analysis indicated that the five-year tumor-free survival rate of AR positive group (71.7%) was lower than that of AR negative group (89.9%) (χ2=5.736，P=0.017）.The Cox regression analysis showed that AR was the independent prognostic factor influencing five-year DFS（RR=3.961，95%CI：1.008~15.574）. ［Conclusion］ AR is highly expressed in Her-2 over-expression breast cancer. The patient with positive AR may have a poorer prognosis. AR might be a novel therapeutic target for Her-2 over-expression breast cancer. |
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