尼 杰.雄激素受体在Her-2过表达型乳腺癌中的意义[J].肿瘤学杂志,2017,23(3):189-193.
雄激素受体在Her-2过表达型乳腺癌中的意义
Clinical Significance of Androgen Receptor in Breast Cancer Patients with Human Epidermal Growth Factor Receptor-2 Overexpression
投稿时间:2016-11-01  
DOI:10.11735/j.issn.1671-170X.2017.03.B006
中文关键词:  乳腺肿瘤  雄激素受体  Her-2过表达型乳腺癌
英文关键词:breast neoplasms  androgen receptor  human epidermal growth factor receptor-2 overexpression  breast cancer
基金项目:邢台市科技支撑计划项目(2015ZC191)
作者单位
尼 杰 邢台医学高等专科学校第二附属医院 
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中文摘要:
      摘 要:[目的] 探讨雄激素受体(androgen receptor,AR)在人表皮生长因子受体-2(human epidermal growth factor receptor-2,Her-2)过表达型乳腺癌中的临床意义。[方法] 用免疫组化方法检测有完整临床及随访资料的102例Her-2过表达型乳腺癌中AR表达,并分析其与临床病理特征及5年无疾病进展时间(disease-free survinal,DFS)的相关性。[结果] AR在Her-2过表达型乳腺癌阳性率为75.5%(77/102);淋巴结阴性组AR表达率为84.91%(45/53),明显高于淋巴结阳性组的65.31%(32/49)(χ2=5.286,P=0.021);Ki-67阴性组AR表达率(89.47%,34/38)明显高于Ki-67阳性组的67.19%(43/64)(χ2=6.400,P=0.011)。生存分析显示,AR阳性组5年无瘤生存率为71.7%,明显低于AR阴性组的89.8%(χ2=5.736,P=0.017)。Cox回归分析显示,AR是影响Her-2过表达型乳腺癌5年DFS的独立预后因素(RR=3.961,95%CI:1.008~15.574)。[结论] AR在Her-2过表达型乳腺癌中的表达率高,AR阳性患者预后较差,AR可能成为Her-2过表达型乳腺癌新的治疗靶点。
英文摘要:
      Abstract:[Objective] To investigate the clinical significance of androgen receptor(AR) in breast cancer with Her-2 overexprssion. [Methods] The expression of AR was detected by immunohistochemical staining in 102 patients with Her-2 over-expression breast cancer. The relationship between AR expression with clinicopathological characteristics and disease-free survival (DFS) was analyzed. [Results] The positive rate of AR expression was 75.5%(77/102). The AR expression in patients with negative lymph nodes was 84.91% (45/53),which was significantly higher than that with positive lymph nodes (65.31%,32/49)(χ2=5.286,P=0.021). The AR expression in patient with negative Ki-67 was 89.47%(34/38),which was significantly higher than that with positive Ki-67 (67.19%,43/64) (χ2=6.400,P=0.011). The survival analysis indicated that the five-year tumor-free survival rate of AR positive group (71.7%) was lower than that of AR negative group (89.9%) (χ2=5.736,P=0.017).The Cox regression analysis showed that AR was the independent prognostic factor influencing five-year DFS(RR=3.961,95%CI:1.008~15.574). [Conclusion] AR is highly expressed in Her-2 over-expression breast cancer. The patient with positive AR may have a poorer prognosis. AR might be a novel therapeutic target for Her-2 over-expression breast cancer.
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