| 钱门龙,万 闹,殷 航.淋巴细胞与单核细胞比值在乳腺癌患者预后评估中的价值[J].肿瘤学杂志,2017,23(3):185-188. |
| 淋巴细胞与单核细胞比值在乳腺癌患者预后评估中的价值 |
| Lymphocyte-to-monocyte Ratio as Prognostic Predictor in Patients with Breast Cancer |
| 投稿时间：2016-10-27 |
| DOI：10.11735/j.issn.1671-170X.2017.03.B005 |
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| 中文关键词: 乳腺肿瘤 淋巴细胞与单核细胞比值 预后 |
| 英文关键词:breast neoplasms lymphocyte-to-monocyte ratio prognosis |
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| 摘要点击次数: 1977 |
| 全文下载次数: 522 |
| 中文摘要: |
| 摘 要：［目的］ 探讨术前外周血中淋巴细胞与单核细胞比值（LMR）在乳腺癌患者预后评估中的价值。［方法］ 回顾性分析2006年1月至2010年12月在新疆军区总医院经术后病理证实92例乳腺癌患者的临床资料。 通过建立受试者工作特征曲线，确定术前LMR最佳临界值为5.83； 按术前LMR值分为高LMR组（LMR≥5.83）与低LMR组(＜5.83)。［结果］ 92例患者术前LMR范围1.47～12.33，平均值为6.00，中位值为5.89。高LMR组与低LMR组患者的临床病理特征差异均无统计学意义(均P＞0.05)。高LMR组和低LMR组患者的5年生存率分别为89.4％和76.7％(P＜0.001)。Cox多因素分析结果显示 LMR是影响患者预后的独立因素（RR＝3.948，95%CI：1.770~8.808）。［结论］ 术前外周血中LMR是预测乳腺癌患者预后的独立因素。 |
| 英文摘要: |
| Abstract：［Objective］ To investigate the prognostic significance of preoperative lymphocyte-to-monocyte ratio (LMR) in patients with breast cancer after radical resection. ［Methods］ The clinical data of 92 patients with breast cancer undergoing radical resection in our hospital between January 2006 and December 2010 were retrospectively analyzed. The receiver operating characteristic curve(ROC curve) was used to analyze the prognostic value of preoperative LMR in breast cancer patients. ［Results］ The median value of LMR was 5.89 (range of 1.47~12.33，the average of 6.00). The 5-year overall survival rate was 89.4% in patients with high LMR(≥5.83，n=49) and 76.7% in those with low LMR(＜5.83，n=43)(P＜0.001)．There was no statistically significant difference in the clinicopathological characteristics between patients with high LMR and those with low LMR. Multivariate analysis revealed that LMR was an independent prognostic factor （RR＝3.948，95%CI：1.770~8.808）for survival of patients.［Conclusion］ Preoperative LMR may be a convenient biomarker for prognosis for breast cancer patients after radical resection． |
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