| 陈茂山,张艳利,杨宏伟.外周血中性粒细胞与淋巴细胞比率和血小板与淋巴细胞比率对乳腺癌新辅助化疗疗效的预测价值[J].肿瘤学杂志,2017,23(3):180-184. |
| 外周血中性粒细胞与淋巴细胞比率和血小板与淋巴细胞比率对乳腺癌新辅助化疗疗效的预测价值 |
| Predictive Value of Peripheral Blood Neutrophil to Lymphocyte Ratio and Platelet to Lymphocyte Ratio in Breast Cancer Patients with Neoadjuvant Chemotherapy |
| 投稿时间：2016-07-27 |
| DOI：10.11735/j.issn.1671-170X.2017.03.B004 |
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| 中文关键词: 乳腺肿瘤 中性粒细胞与淋巴细胞比率 血小板与淋巴细胞比率 新辅助化疗 |
| 英文关键词:breast neoplasms neutrophil to lymphocyte ratio platelet to lymphocyte ratio neoadjuvant chemotherapy |
| 基金项目:遂宁市中心医院科研立项 |
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| 中文摘要: |
| 摘 要：［目的］ 评价外周血中性粒细胞与淋巴细胞比率（NLR）和血小板与淋巴细胞比率（PLR）对乳腺癌新辅助化疗疗效的预测价值。［方法］ 回顾性分析394例接受新辅助化疗（NAC）乳腺癌患者治疗前血液NLR、PLR分布情况，采用受试者工作特征曲线（ROC）法评估NLR、PLR对NAC疗效达病理完全缓解（pCR）的预测价值。［结果］ NAC后pCR率为17.0%，pCR组NLR、PLR分别为1.64±0.5、120.7±37.7，非pCR组分别为2.4±1.1、142.0±46.2，组间差异有统计学意义（P﹤0.001）；NLR、PLR鉴别pCR的受试者工作特征曲线（ROC）的曲线下面积（AUC）分别为0.75、0.64；NLR（≥1.6）、PLR（≥120.7）预测乳腺癌NAC后pCR率的敏感性分别为76.8%、62.6%，特异性分别为60.3%、62.6%；二分类Logistic回归分析显示NLR水平是NAC疗效的独立预测因素。［结论］ 治疗前外周血高水平NLR预示乳腺癌NAC后的pCR率更低。 |
| 英文摘要: |
| Abstract：［Objective］ To investigate predictive value of peripheral blood neutrophil to lymphocyte ratio(NLR) and platelet to lymphocyte ratio(PLR) in breast cancer patients with neoadjuvant chemotherapy (NAC). ［Methods］ Retrospective study was performed in 394 breast cancer patients receiving NAC. The distribution of NLR and PLR before NAC were analyzed. Receiver operating characteristic curve(ROC) was used to evaluate the predictive value of NLR and PLR in differentiating the patients with or without pathological complete response(pCR) after NAC.［Results］ The overall pCR in this group of patients was 17.0%. NLR and PLR in pCR patients were 1.6±0.5，120.7±37.7；and those in non-pCR patients were 2.4±1.1，142.0±46.2(P<0.001). Area under ROC（AUC） of NLR and PLR was 0.75 and 0.64，respectively. Taking 1.6 and 120.7 as cutoff values of NLR and PLR，the sensitivities of NLR and PLR were 76.8%，62.6%；and the specificities were 60.3%，62.6%，respectively. Logistic regression analysis of binary classification showed that NLR was an independent predictor of NAC efficacy.［Conclusion］ Higher peripheral blood NLR level before chemotherapy can predict the efficacy in patients with breast cancer receiving neoadjuvant chemotherapy. |
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