李 婉,马 荣.单核苷酸多态性在恶性肿瘤精准医学研究中的意义[J].肿瘤学杂志,2017,23(2):134-139. |
单核苷酸多态性在恶性肿瘤精准医学研究中的意义 |
Significance of Single Nucleotide Polymorphisms in Precision Medicine of Malignancy |
投稿时间:2016-07-21 |
DOI:10.11735/j.issn.1671-170X.2017.02.B012 |
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中文关键词: 单核苷酸多态性 精准医学 恶性肿瘤 |
英文关键词:single nucleotide polymorphisms precision medicine malignancy |
基金项目:黑龙江省留学归国科学基金项目(LC2012C14) |
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中文摘要: |
摘 要:精准医学是应用现代医学前沿技术结合患者生活环境和临床数据,实现疾病的精准分类及诊断,制定个性化的疾病预防和治疗方案的新型医学概念和医疗模式。单核苷酸多态性(SNP)是导致人类基因组变化的最根本原因。SNP研究是人类基因组计划应用的重要步骤,用于高危群体的发现、疾病相关基因的鉴定、药物的设计和测试以及生物学的基础研究等。本文就SNP在恶性肿瘤精准医学中的意义作简要综述。 |
英文摘要: |
Abstract:Precision medicine is a new medical concept and model,which applies the cutting-edge technology integrated with the environmental factors and clinical data of patients,to make accurate classification and diagnosis of disease,and to develop a personalized prevention and treatment strategy. Single nucleotide polymorphism(SNP) is the fundamental cause of the change of the human genome. SNP research is an important approach to identify disease genes,discover high-risk groups,and to design and test the effective drugs,as well as to undertake the basic biological research. In this article,the significance of SNP in precision medicine of malignant tumor is reviewed. |
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