| 范立凤,刘慧敏.TFF3和VEGF表达与胃癌发生、浸润和转移的相关性[J].肿瘤学杂志,2017,23(2):125-129. |
| TFF3和VEGF表达与胃癌发生、浸润和转移的相关性 |
| Expression of TFF3 and VEGF in Gastric Cancer and Their Clinicopathological Significance |
| 投稿时间：2016-07-13 |
| DOI：10.11735/j.issn.1671-170X.2017.02.B010 |
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| 中文关键词: 胃肿瘤 三叶因子3 血管内皮生长因子 免疫组织化学 |
| 英文关键词:gastric neoplasms trefoil factor 3 vascular endothelial growth factor immunochemistry |
| 基金项目:十堰市科学技术研究与开发项目（14Y49） |
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| 中文摘要: |
| 摘 要：［目的］ 探讨TFF3和VEGF的表达与胃癌发生、浸润和转移的相关性。［方法］ 采用免疫组织化学SP法检测70例胃癌组织及其癌旁组织、40名健康体检者的正常胃黏膜组织中TFF3和VEGF的表达情况。［结果］ TFF3 和VEGF在正常胃组织、癌旁组织和胃癌组织中的阳性表达率分别为5.0%、40.0%、58.6%和2.5%、47.1%、67.10%，同一指标组间比较差异均有统计学意义（P＜0.05）。TFF3在胃癌组织中的表达与局部淋巴结转移、TNM分期、预后有关，VEGF则与肿瘤分化程度、浆膜浸润程度、局部淋巴结转移、TNM分期、预后有关（P＜0.05）。TFF3和VEGF在胃癌中的表达呈正相关（r=0.532，P＜0.05）。［结论］ TFF3和VEGF的表达可能与胃癌的发生、浸润、转移和预后有关，两者在胃癌中的表达呈正相关，对胃癌的发生可能有协同作用。 |
| 英文摘要: |
| Abstract：［Objective］ To investigate the expression of TFF3 and VEGF in gastric cancer and their clinicopathological significance. ［Methods］ The expression of VEGF and TFF3 were detected with SP immunohistochemical method in cancer and adjacent tissues of 70 gastric cancer patients and in normal gastric mucosa of 40 healthy subjects. ［Results］ There were significant differences in expression rates of TFF3 and VEGF among normal gastric mucosa，cancer-adjacent tissues and gastric carcinoma(P<0.05). The expression of TFF3 in gastric cancer tissues was associated with lymph node metastasis，TNM staging and prognosis，while the expression of VEGF was associated with tumor differentiation，serosal infiltration，lymph node metastasis，TNM staging and prognosis(P<0.05). The expressions of TFF3 and VEGF in gastric cancer were positively correlated with each other(r=0.532，P<0.05). ［Conclusion］ The results indicate that the expression of TFF3 and VEGF may be associated with the occurrence，invasion，metastasis and prognosis of gastric cancer. |
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