| 陈小军,何 侠.中国人群XRCC1 Arg399Gln 基因多态性与结直肠癌易感性关系的Meta分析[J].肿瘤学杂志,2017,23(2):87-91. |
| 中国人群XRCC1 Arg399Gln 基因多态性与结直肠癌易感性关系的Meta分析 |
| Association Between XRCC1 Arg399Gln Polymorphism and Susceptibility of Colorectal Cancer in Chinese Population:A Meta-analysis |
| 投稿时间：2016-09-01 |
| DOI：10.11735/j.issn.1671-170X.2017.02.B002 |
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| 中文关键词: X线修复交叉互补基因1 结直肠肿瘤 基因多态性 Meta分析 |
| 英文关键词:XRCC1 colorectal neoplasms polymorphism Meta-analysis |
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| 中文摘要: |
| 摘 要：［目的］探讨X线修复交叉互补基因1（X-ray repair cross complementing group 1，XRCC1）Arg399Gln基因多态性与中国人群结直肠癌易感性的关系。［方法］在PubMed、MEDLINE、EMBASE、中国知网、维普、中国生物医学文献及万方数据库中检索建库至2016年4月10日之间发表的有关XRCC1 Arg399Gln基因多态性与中国人群结直肠癌易感性关系的相关文献。按照纳入和排除标准独立选择文献、提取资料，采用Stata 12.0软件进行Meta分析，计算合并比值比（OR）及其95%可信区间（95%CI），并进行敏感性分析和发表偏倚的估计。［结果］ 共纳入11项研究，包括3502例患者和4828例对照者。Meta分析结果显示，在Gln/Gln vs Arg/Gln遗传模型中，XRCC1 Arg399Gln基因多态性与中国人群结直肠癌发生风险有显著相关性，与基因型Arg/Gln相比，基因型Gln/Gln增加了中国人群罹患结直肠癌的风险（OR=1.23，95%CI：1.04~1.46，P=0.016）。其余遗传模型中两者间无明显相关性。［结论］ 在Gln/Gln vs Arg/Gln遗传模型中，XRCC1 Arg399Gln基因多态性与中国人群结直肠癌易感性相关，基因型Gln/Gln增加中国人群罹患结直肠癌的风险。 |
| 英文摘要: |
| Abstract：［Objective］ To explore the association between XRCC1 Arg399Gln polymorphism and susceptibility of colorectal cancer in Chinese population. ［Methods］ PubMed，MEDLINE，EMBASE，CNKI，VIP，CBM and WanFang databases were searched for all studies related to XRCC1 Arg399Gln polymorphism and colorectal cancer risk in Chinese population from the incipience to April 2016. The studies meeting inclusion and exclusion criteria were identified. Publication bias and sensitivity were evaluated，and the pooled ORs with 95%CIs were calculated by Stata 12.0 software.［Results］ Eleven studies comprising 3502 cases and 4828 controls were finally included. Meta-analysis showed that there was significant correlation between XRCC1 Arg399Gln polymorphism and colorectal cancer. Compared to Arg/Gln，Gln/Gln genotype increased the susceptibility of colorectal cancer in Chinese population(OR=1.23，95%CI：1.04~1.46，P=0.016). There was no significant correlation between XRCC1 Arg399Gln polymorphism and susceptibility of colorectal cancer in the remaining gene models. ［Conclusion］ The study shows that XRCC1 Arg399Gln Gln/Gln genotype may increase the susceptibility of colorectal cancer in Chinese population. |
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