| 中文关键词: 胸部肿瘤 放射疗法，放射性食管炎 不良反应 |
| 英文关键词:thoracic neoplasms radiotherapy radiation esophagitis toxicities |
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| 中文摘要: |
| 摘 要：放射治疗是胸部肿瘤的主要治疗手段之一，放射性食管炎是胸部肿瘤患者放疗时常见的不良反应，其发生及严重程度影响患者放射治疗的依从性及疗效。目前研究发现，放射性食管炎的发生与患者临床特征、放疗物理剂量学参数、基因分子标志物等有关。根据放射性食管炎发生相关因素，识别发生放射性食管炎的高危患者，对于制定合理的治疗策略、减少放射性食管炎的发生风险、提高治疗疗效至关重要。文章就放射性食管炎发病相关因素的研究进展作一综述。 |
| 英文摘要: |
| Abstract：One of the challenges in thoracic radiotherapy is the development of severe dose-limiting side effects. Esophagus is one of the critical organs at risk(OAR) when radiotherapy is delivered to the thorax. Compared to radiotherapy alone，concurrent chemo-radiotherapy appears to lower esophageal radiation tolerance. Radiation esophagitis is a common radiation induced toxicity occurring in patients following the treatment. Studies about the predictors for the development of esophagitis indicate that clinical features，dosimetric and physical parameters，molecular biomarkers of the patients may be associated with the pathogenesis of esophagitis. Identifying patients who might be at increased risk for esophagitis is crucial for administering the optimal therapeutic strategies to mitigate risk and thus improve treatment efficacy. This review summarizes the advances in the pathogenesis of radiation esophagitis to provide some new evidence of prevention. |
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