| 李 聪,张 悦,任延律.整合素β3在三阴性乳腺癌中的表达及其与预后的关系[J].肿瘤学杂志,2016,22(12):1037-1041. |
| 整合素β3在三阴性乳腺癌中的表达及其与预后的关系 |
| Expression of Integrin β3 in Triple Negative Breast Cancer and Its Prognostic Significance |
| 投稿时间：2016-05-08 |
| DOI：10.11735/j.issn.1671-170X.2016.12.B011 |
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| 中文关键词: 三阴性乳腺癌 整合素β3 预后 |
| 英文关键词:integrin β3 triple negative breast cancer prognosis |
| 基金项目:黑龙江省自然科学基金项目（H2015051） |
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| 中文摘要: |
| 摘 要：［目的］ 探讨整合素β3在三阴性乳腺癌中的临床意义。［方法］ 免疫组织化学染色法检测98例三阴性乳腺癌组织中整合素β3的表达情况。［结果］ 在三阴性乳腺癌患者中整合素β3表达与患者的绝经状态及淋巴结转移状态密切相关(P<0.05)。整合素β3阳性的三阴性乳腺癌患者的5年无病生存时间及乳腺癌特异性生存时间均显著差于整合素β3阴性者。Cox多因素分析显示整合素β3是三阴性乳腺癌预后不良的独立危险因素(HR=1.910，95%CI：1.069~3.413；P=0.029）。［结论］ 整合素β3可作为判断三阴性乳腺癌预后的重要指标及潜在的治疗靶点。 |
| 英文摘要: |
| Abstract：［Objective］ To explore the clinical significance of integrin β3expression in triple negative breast cancer (TNBC). ［Methods］ The expression of integrin β3 was detected in 98 patients with TNBC by immunohistochemical staining. ［Results］ Integrin β3 was significantly associated with menopausal status and lymph node status(P<0.05). Patients with positive integrin β3 expression had worse 5-year disease-free survival and breast cancer-specific survival than patients with negative expression. Cox multivariate analysis showed that integrin β3 was an independent unfavorable prognostic factor for patients with TNBC(HR=1.910，95%CI：1.069～3.413；P=0.029）. ［Conclusion］ Integrin β3 can be used as the prognostic marker and potential therapy target for TNBC. |
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