康富标,王 玲,彭焕彦.人肝细胞癌组织肿瘤相关巨噬细胞的浸润水平及其临床意义[J].肿瘤学杂志,2016,22(11):923-927.
人肝细胞癌组织肿瘤相关巨噬细胞的浸润水平及其临床意义
Infiltration Level of Tumor-associated Macrophages in Human Hepatocellular Carcinoma and Its Clinical Significance
投稿时间:2016-01-27  
DOI:10.11735/j.issn.1671-170X.2016.11.B011
中文关键词:  肝肿瘤  肿瘤相关巨噬细胞  CD68  免疫组织化学
英文关键词:hepatocellular neoplasms  tumor-associated macrophages  CD68  immunohistochemistry
基金项目:
作者单位
康富标 白求恩国际和平医院 
王 玲 河北医科大学第四医院 
彭焕彦 白求恩国际和平医院 
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中文摘要:
      摘 要:[目的] 通过检测人肝细胞癌组织中肿瘤相关巨噬细胞的浸润水平和特点,探讨肿瘤相关巨噬细胞在肝癌发生、进展中的作用。[方法] 以CD68分子为巨噬细胞标志,采用免疫组织化学法检测116例肝细胞癌肿瘤组织巨噬细胞的浸润水平和特点。[结果] 肝细胞癌组织中CD68阳性表达率为94.8%(110/116),而癌旁组织为17.2%(20/116)。巨噬细胞的浸润水平在不同TNM分期、是否存在血管侵袭、淋巴结转移及微卫星病灶分组间均有统计学差异(P<0.05),与患者预后呈负相关(P=0.001)。[结论]人肝细胞癌组织肿瘤相关巨噬细胞呈高浸润状态,且浸润水平与多项临床病理特征和预后密切相关,提示其可能参与了肝癌的发生、进展。
英文摘要:
      Abstract:[Objective] To examine the level and characteristics of tumor-associated macrophage in human hepatocellular carcinoma (HCC) and to evaluate its role in the progression of HCC. [Methods] Macrophages marked by CD68 molecule in liver tissues from 116 patients with HCC were examined by immunochemistry staining. [Results] About 94.8%(110/116) samples were positive for CD68 in these tumor specimens,while 17.2%(20/116) in adjacent tissues. Significant differences of macrophages’ infiltration were found among early and late TNM stages and exists or not of vascular invasion,lymph metastasis and microsatellite lesions(P<0.05). Meanwhile,the levels of macrophages in tumor tissues were negatively correlated with postoperative prognosis(P=0.001). [Conclusions] Macrophages are shown high infiltration levels in HCC tissues and closely relate to several clinical parameters,tumor staging and survival of HCC. Therefore,TAMs might involve in the mechanisms of HCC.
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