| 徐慧媛,周韶璋,宋向群.HGF、c-Met、p-Met在NSCLC中的表达及与EGFR表达的相关性[J].肿瘤学杂志,2016,22(11):917-922. |
| HGF、c-Met、p-Met在NSCLC中的表达及与EGFR表达的相关性 |
| Expression of HGF，c-Met and p-Met in Non-small Cell Lung Cancer and Their Relation to EGFR Expression |
| 投稿时间：2016-03-23 |
| DOI：10.11735/j.issn.1671-170X.2016.11.B010 |
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| 中文关键词: HGF c-Met 癌，非小细胞肺 EGFR |
| 英文关键词:HGF c-Met non-small cell lung cancer EGFR |
| 基金项目:国家自然科学基金资助项目（81260357、81060188） |
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| 中文摘要: |
| 摘 要：［目的］ 通过检测非小细胞肺癌患者中HGF、c-Met和p-Met的表达情况，分析其与临床病理特征关系，并与EGFR表达的相关性。［方法］ 收集经手术切除非小细胞肺癌患者的标本100例，采用免疫组化方法检测HGF、c-Met、p-Met蛋白的表达水平，并收集这些患者既往检测EGFR的表达情况。［结果］ HGF阳性表达率为64%，c-Met阳性表达率为47%，p-Met阳性表达率为3%。HGF、c-Met的表达与吸烟状态、年龄、性别、临床分期、分化程度、病理类型均无统计学差异；p-Met阳性表达患者均为EGFR突变的HGF强表达的腺癌患者。HGF、c-Met的表达水平与EGFR表达水平无相关性。［结论］ HGF、c-Met的阳性表达与吸烟状态、年龄、性别、临床分期、分化程度、病理类型以及EGFR的表达水平均无关。p-Met的阳性表达患者均为HGF强表达的腺癌EGFR突变型。 |
| 英文摘要: |
| Abstract：［Objective］To investigate the expression of HGF，c-Met，p-Met in non-small cell cancer (NSCLC) and their relation to the expression of epidermal growth factor receptor (EGFR). ［Methods］ The expressions of the HGF，c-Met and p-Met were detected by immunohistochemistry in 100 tissue specimens of NSCLC. The results of EGFR expression was taken from pathological reports. ［Results］ The positive expression rates of HGF，c-Met and p-Met were 64%，47% and 3%，respectively. No correlation was found in the expression of HGF and c-Met with smoking status，age，gender，clinical stage，degree of pathological differentiation or histological type(P>0.05). Positive p-Met was only observed in adenocacinoma patients with EGFR mutation and strongly expressed HGF. The expression of c-Met and HGF was not correlated with EGFR expression.［Conclusion］ This study has not showed the correlation of HGF and c-Met expression with clinicopathological features of NSCLC patients，but shown an association of p-Met expression with EGFR-mutated lung adenocacinoma. |
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