| 邹雨婷,陈 跃.高危分化型甲状腺癌131I治疗后PET/CT的应用价值[J].肿瘤学杂志,2016,22(11):897-901. |
| 高危分化型甲状腺癌131I治疗后PET/CT的应用价值 |
| The Value of PET/CT in High-risk Differentiated Thyroid Carcinoma After Radioiodione Therapy |
| 投稿时间：2016-06-01 |
| DOI：10.11735/j.issn.1671-170X.2016.11.B006 |
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| 中文关键词: 甲状腺肿瘤 碘放射性同位素 正电子发射断层显像术 体层摄影术，X线计算机 |
| 英文关键词:thyroid neoplasms iodine radioisotopes positron emission tomography tomography,X-ray computed |
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| 摘要点击次数: 1738 |
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| 中文摘要: |
| 摘 要：［目的］ 探讨18F-FDG PET/CT在高危分化型甲状腺癌131I治疗后的临床应用价值。［方法］ 23例高危分化型甲状腺癌患者全切或近全切术后4周行131I治疗，并在131I治疗后的1周内分别行18F-FDG PET/CT与131I全身扫描（131I-WBS），以术后病理活检或至少6个月的影像随访作为诊断标准。分析18F-FDG PET/CT在随访中的临床应用价值。［结果］检查后发现16例发生转移，18F-FDG PET/CT检出其中15例（93.8%），与131I-WBS检出其中5例（31.3%）比较，差异有统计学意义（P=0.006）。在随访中，TNM分期改变的患者有6例（26.1%），患者管理改变有15例（56.5%）且分别为手术切除、靶向治疗、局部外照射等治疗。［结论］在临床实践中，18F-FDG PET/CT能检测出131I-WBS阴性病灶，具有更高的灵敏度和阴性预测值，使患者获得最佳治疗方案而改善预后。 |
| 英文摘要: |
| Abstract：［Objective］ To study the clinical value of 18F-FDG PET/CT in high-risk DTC after radioiodione therapy. ［Methods］ Radioiodine treatment was performed in 23 patients with high-risk differentiated thyroid carcinoma approximately 4 weeks after total or near total thyroidectomy.Then they received 18F-FDG PET/CT and 131I-WBS within a week. The results were analyzed according to postoperative pathological biopsy or imaging follow-up of at least 6 months as diagnostic criteria.The clinical value of 18F-FDG PET/CT in follow-up was analyzed. ［Results］ The exa-minations uncovered that metastasis occured in 16 cases out of the 23 cases. 18F-FDG PET/CT revealed metastasis lesions in 15 cases (93.8%)，while 131I-WBS in 5 cases （31.3%），the difference with statistic significance(P=0.006). During follow-up，TNM staging was changed in 6 patients (26.1%)，and management was changed in 15 patients (56.5%) treated with surgical resection，targeted therapy and local external irradiation，respectively. ［Conclusion］ In clinical practice，18F-FDG PET/CT with higher sensitivity and negative predictive value can detect 131I-WBS negative lesions so that patients get the best treatment options to improve the prognosis. |
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