金雅琼,冯 林,初 平.KDM4A在儿童和成人甲状腺乳头状癌中的表达及诊断价值[J].肿瘤学杂志,2016,22(10):838-843. |
KDM4A在儿童和成人甲状腺乳头状癌中的表达及诊断价值 |
Expression and Diagnostic Value of KDM4A in Papillary Thyroid Carcinoma of Children and Adults |
投稿时间:2016-05-04 |
DOI:10.11735/j.issn.1671-170X.2016.10.B012 |
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中文关键词: KDM4A 甲状腺肿瘤 受试者工作特征曲线 |
英文关键词:KDM4A papillary thyroid carcinoma receiver operating characteristic curve |
基金项目:国家自然科学基金(81502144);北京市科技计划(D131100005313014);首都医科大学基础-临床科研合作基金 (15JL69);北京市优秀人才培养资助(2015000021469G210) |
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中文摘要: |
摘 要:[目的] 探讨KDM4A在儿童和成人甲状腺乳头状癌中的表达及诊断价值。[方法] 采用实时荧光定量PCR的方法进行组织KDM4A表达检测,其中甲状腺乳头状癌组织样本22例,癌旁组织样本13例(配对样本共13对)。其中,儿童甲状腺乳头状癌样本10例,癌旁组织3例(配对样本3对);成人甲状腺乳头状癌标本12例,癌旁组织10例(配对样本10对)。并采用受试者工作特征(ROC)曲线对其诊断价值进行评估。[结果] 甲状腺乳头状癌组织较配对癌旁组织中KDM4A表达显著增高(P=0.011),非配对比较甲状腺乳头状癌组织较癌旁组织中KDM4A表达显著增高(P=0.027);KDM4A诊断PTC的ROC曲线下面积指数为0.794(P=0.004)(Youden指数0.538);儿童甲状腺乳头状癌中KDM4A表达略高于成人(P>0.05),且儿童甲状腺乳头状癌标本中KDM4A的ROC曲线下面积指数为0.831(P=0.007)(Youden指数0.615),高于成人标本的0.763,P=0.026 (Youden指数0.538)。[结论] KDM4A表达在甲状腺乳头状癌中显著高于癌旁组织,并明确了KDM4A具有诊断价值。此外,本研究还明确了KDM4A作为分子标志物在儿童甲状腺乳头状癌中的诊断价值高于成人。 |
英文摘要: |
Abstract:[Objective] To investigate the expression of KDM4A and its diagnostic value in papillary thyroid carcinoma(PTC) of children and adults.[Methods] The expression of KDM4A was detected by real time-PCR in 22 specimens of PTC(10 from children,12 from adults) and 13 specimens of pericarcerous tissues(3 from children and 10 from adults). Receiver operating characteristic(ROC) curve and Youden’s index were calculated to evaluate the diagnostic value of KDM4A in children and adults PTC.[Results] The expression of KDM4A in PTC was higher than that in pericarcerous tissues. The area under curve(AUC) in ROC was 0.794(P=0.004) with a Youden’s index of 0.538. Furthermore,the expression of KDM4A in children PTC was higher than that in adults(P>0.05),the AUC in children was 0.831(P=0.007) with a Youden’s index of 0.615,while that was 0.763(P=0.026) with Youden’s index of 0.538 in adults. [Conclusion] The expression of KDM4A is up-regulated in PTC,indicating it can be used as a potential indicator for PTC,particularly in children. |
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