| 马 娟,李晓雯.结肠癌合并2型糖尿病患者血清IGF-2、IGFBP-2升高与肿瘤复发的关系[J].肿瘤学杂志,2016,22(10):806-809. |
| 结肠癌合并2型糖尿病患者血清IGF-2、IGFBP-2升高与肿瘤复发的关系 |
| Association of Increased Serum IGF-2 and IGFBP-2 Levels with Tumor Recurrence in Type 2 Diabetic Patients with Colon Cancer |
| 投稿时间：2016-03-16 |
| DOI：10.11735/j.issn.1671-170X.2016.10.B006 |
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| 中文关键词: 结肠肿瘤 2型糖尿病 IGF-2 IGFBP-2 复发 |
| 英文关键词:colon neoplasms type 2 diabetes IGF-2 IGFBP-2 recurrence |
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| 摘要点击次数: 1708 |
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| 中文摘要: |
| 摘 要：［目的］ 观察结肠癌合并2型糖尿病患者血清胰岛素样生长因子-2(IGF-2)及胰岛素样生长因子结合蛋白-2(IGFBP-2)升高与结肠癌复发的关系。［方法］ 选择结肠癌合并2型糖尿病患者90例为观察对象，以同期在院治疗合并2型糖尿病的良性结肠疾病患者90例为对照，在结肠癌术后1周时检测其血清IGF-2、IGFBP-2水平，与对照组进行比较，记录结肠癌患者在1年中复发的数据，按复发与否，描绘IGF-2、IGFBP-2水平与复发关系的ROC曲线图，观察IGF-2、IGFBP-2水平与复发的关系，统计IGF-2、IGFBP-2水平预测复发的灵敏度、特异性。［结果］ 结肠癌患者血清IGF-2、IGFBP-2水平明显高于对照组，具有统计学差异；IGF-2、IGFBP-2水平升高与结肠癌复发存在相关性，具有统计学差异（P<0.05）。［结论］ 结肠癌合并2型糖尿病患者血清IGF-2、IGFBP-2升高，并与结肠癌术后的复发相关。 |
| 英文摘要: |
| Abstract：［Objective］ To investigate the association of increased serum insulin-like growth factor-2(IGF-2) and insulin-like growth factor binding protein -2(IGFBP-2) levels with tumor recurrence in. ［Methods］ Ninety type 2 diabetic patients with colon cancer(cancer group) and 90 type 2 diabetic patients with benign colonic diseases(control group) were enrolled in the study. Serum IGF-2 and IGFBP-2 were detected 1 wk after operation(cancer group) or at admission(control group). Tumor recurrence within 1 y after surgery was documented. The association of rumor recurrence with serum IGF-2 and IGFBP-2 levels was analyzed by receiver operating characteristic(ROC) curve，the sensitivity and specificity of IGF-2 and IGFBP-2 in predicting recurrence were calculated. ［Results］ The serum levels of IGF-2 and IGFBP-2 in colon cancer patients were significantly higher than those in the control group(P<0.05).IGF-2 and IGFBP-2 levels were significantly correlated with the recurrence of colon cancer(P<0.05). ［Conclusion］ The serum levels of IGF-2 and IGFBP-2 in type 2 diabetic patients with colon cancer are related to the tumor recurrence. |
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