| 姜姗姗,辛 彦.MELK与胃肠道肿瘤关系的研究进展[J].肿瘤学杂志,2016,22(10):777-782. |
| MELK与胃肠道肿瘤关系的研究进展 |
| Research Progress on Relationship Between MELK and Gastrointestinal Tumors |
| 投稿时间：2016-07-05 |
| DOI：10.11735/j.issn.1671-170X.2016.10.B001 |
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| 中文关键词: MELK 细胞周期 胃肠道肿瘤 治疗靶点 |
| 英文关键词:MELK cell cycle gastrointestinal cancer therapeutic target |
| 基金项目:国家自然科学基金（81071650、30973503）；辽宁省科技厅科学技术计划项目（2013225303-103、2011404013-3） |
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| 中文摘要: |
| 摘 要：母体胚胎亮氨酸拉链激酶(MELK)是一种Ser/Thr蛋白激酶，也是一种细胞周期依赖性蛋白激酶，属于蔗糖非发酵-1/AMP活化蛋白激酶(Snf1/AMPK)家族。最近研究发现，MELK在许多肿瘤细胞中表达水平增高，其高表达能够抑制肿瘤细胞及某些干细胞的分化与凋亡，并促进肿瘤细胞增殖，与许多恶性肿瘤的不良预后密切相关，被认为是一种原癌基因。此外，MELK参与多种信号通路调控，促进细胞增殖和肿瘤形成。MELK沉默有望成为肿瘤新的治疗靶点之一。本文就MELK的结构、功能、表达调控及与胃肠道肿瘤关系的研究进展作一综述。 |
| 英文摘要: |
| Abstract：Maternal embryonic leucine zipper kinase (MELK)，a member of the sucrose-non-fermenting (SNF1)/AMPK family of serine-threonine kinases，is a cell cycle dependent protein kinase. Recently，overexpression of MELK has been detected in a variety of human tumors，which can inhibit cell differentiation，apoptosis of tumor cells and tumor stem cells，and promote proliferation of tumor cells. MELK expression is correlated with poor prognosis of a variety of cancers，and known as an oncogen. In addition，MELK is involved in the regulation of many signaling pathways，which drive cell proliferation and tumor formation. Knockdown of MELK may be a new target for cancer treatment. This article aims to review the latest research progress of the structure，function and expression regulation of MELK in gastrointestinal cancer. |
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