| 杜 雄,李延新.Atg5与P504S在82例前列腺癌中的表达研究[J].肿瘤学杂志,2016,22(9):738-741. |
| Atg5与P504S在82例前列腺癌中的表达研究 |
| Expressions of Atg5 and P504S in 82 Cases with Prostatic Cancer |
| 投稿时间：2016-04-12 |
| DOI：10.11735/j.issn.1671-170X.2016.09.B010 |
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| 中文关键词: Atg5 P504S 前列腺肿瘤 良性前列腺增生症 前列腺上皮内瘤 |
| 英文关键词:Atg5 P504S prostatic neoplasms benign prostatic hyperplasia prostatic intraepithelial neoplasia |
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| 中文摘要: |
| 摘 要：［目的］ 探讨Atg5与P504S在前列腺癌中的表达情况。［方法］ 收集前列腺癌（PCa）、良性前列腺增生症（BPH）及前列腺上皮内瘤（PIN）的组织标本共127例，其中PCa组织标本82例，BPH组织标本25例，PIN组织标本20例。采用免疫组化法检测Atg5与P504S在不同病变组织中的表达情况。［结果］ Atg5与P504S在PCa组织中的阳性率均显著高于BPH及PIN组织，差异具有统计学意义（P<0.05）。P504S的阳性表达程度与病理分级、临床分期以及肿瘤转移有关，而与患者年龄无关。Atg5的表达与年龄、病理分级、临床分期以及肿瘤转移均无显著相关性（P>0.05）。Atg5与P504S在PCa组织中的表达呈正相关（P<0.05）。［结论］ Atg5与P504S的异常表达与前列腺癌密切相关，且P504S与前列腺癌进展呈正相关，在前列腺癌诊断中具有较高的临床价值。 |
| 英文摘要: |
| Abstract：［Objective］ To investigate the expressions of Atg5 and P504S in prostatic cancer (PCa) tissues.［Methods］ The expressions of Atg5 and P504S were detected immunohistochemically in 82 specimens of PCa tissue，25 specimens of benign prostatic hyperplasia (BPH) and 20 specimens of prostatic intraepithelial neoplasia(PIN).［Results］ Positive rates of Atg5 and P504S in PCa tissues were significantly higher than those in BPH and PIN tissues(P<0.05). Positive expression of P504S was correlated with pathologic grade，clinical stage and tumor metastasis；but not correlated with age of patients. No correlation of Atg5 expression with age，pathologic rade，clinical stage and tumor metastasis were observed(P>0.05). There was positive correlation between Atg5 and P504S in PCa(P<0.05).［Conclusion］ Abnormal expressions of Atg5 and P504S are closely related to PCa. P504S has positive correlation with progress of PCa，which may have clinical value in diagnosis of PCa. |
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