| 林道浙,潘升华,庄微雅.HMGI-C在预测乳腺癌患者表阿霉素治疗疗效中的作用[J].肿瘤学杂志,2016,22(9):733-737. |
| HMGI-C在预测乳腺癌患者表阿霉素治疗疗效中的作用 |
| Expression of HMGI-C in Prediction of Efficacy of Epirubicin in Treatment of Breast Cancer |
| 投稿时间：2016-04-26 |
| DOI：10.11735/j.issn.1671-170X.2016.09.B009 |
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| 中文关键词: 乳腺肿瘤 HMGI-C 表阿霉素 药物疗法 |
| 英文关键词:breast neoplasms HMGI-C epirubicin drug therapy |
| 基金项目:浙江省自然科学基金资助项目（LY14H160043）；温州市科技计划项目（Y20130308） |
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| 中文摘要: |
| 摘 要：［目的］ 探讨高迁移率族蛋白HMGI-C在预测乳腺癌患者表阿霉素治疗效果中的作用。［方法］ 接受表阿霉素新辅助化疗的乳腺癌患者62例，检测其癌组织标本的HMGI-C表达情况，并分析其表达和表阿霉素治疗疗效的关系。［结果］ 62例乳腺癌患者HMGI-C蛋白总体阳性率为48.4%（30/62）；HMGI-C阳性乳腺癌患者表阿霉素治疗有效率显著高于阴性患者(P<0.05)；HMGI-C的表达与乳腺癌组织学分级、Ki-67及Her-2呈正相关(P<0.05)，与ER 及PR呈负相关(P<0.05)，与年龄无关。［结论］ HMGI-C表达情况与乳腺癌患者表阿霉素治疗疗效有密切关系，HMGI-C阳性表达强度越高，患者表阿霉素化疗有效率也越高，可作为预测表阿霉素化疗敏感性的指标。 |
| 英文摘要: |
| Abstract：［Objective］ To investigate the expression of high mobility group protein (HMGI-C) in predicting the therapeutic effect of epirubicin in breast cancer.［Methods］ Sixty-two breast cancer patients receiving neoadjuvant chemotherapy with epirubicin were enrolled in the study. The expression of HMGI-C in cancer tissues was detected by immunohistochemistry and the relationship between HMGI-C expression and therapeutic effect of epirubicin was analyzed. ［Results］ The overall positive rate of HMGI-C in 62 cases of breast cancer patients was 48.4%(30/62). HMGI-C positive patients were more sensitive to epirubicin than HMGI-C negative patients(P<0.05). The expression of HMGI-C was positively correlated with tumor grade，expressions of Ki-67 and Her-2(P<0.05)，and negatively correlated with ER and PR(P<0.05)，but no association was observed with age of patients. ［Conclusion］ HMGI-C expression is closely related to therapeutic effect of epirubicin in breast cancer，indicating that HMGI-C can be used as a marker for sensitivity to epirubicin of breast cancer. |
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