| 刘 念,彭 艳,郑金华.口腔鳞癌侵袭方式与α-SMA、胶原纤维表达的相关性对预后的影响[J].肿瘤学杂志,2016,22(9):727-732. |
| 口腔鳞癌侵袭方式与α-SMA、胶原纤维表达的相关性对预后的影响 |
| Correlation of Collagen Fiber and α-SMA Expression with Invasion Pattern and Prognosis of Oral Squamous Cell Carcinoma |
| 投稿时间：2016-01-12 |
| DOI：10.11735/j.issn.1671-170X.2016.09.B008 |
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| 中文关键词: 口腔肿瘤 鳞状细胞癌 侵袭方式等级积分 α-SMA 胶原纤维 |
| 英文关键词:oral neoplasms squamous cell carcinoma invasive pattern grading score α-SMA collagen fiber |
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| 中文摘要: |
| 摘 要：［目的］检测肌成纤维细胞标志物?琢-SMA和胶原纤维在人口腔鳞状细胞癌（oral squamous cell carcinoma，OSCC）的表达情况，探讨它们的表达与癌侵袭方式等级积分（Invasive pattern grading score，IPGS）间的关系及对预后的影响。 ［方法］ 采用HE染色判定侵袭方式等级积分；Masson染色和免疫组化分析胶原面积百分比（collagen area percentage，CAP）和?琢-SMA的阳性百分率，并进行统计学分析。［结果］ 80例OSCC样本在IPGS＜5组和≥5组的病例数分别为32和48例。?琢-SMA强阳性比例和CAP在IPGS＜5组和≥5组存在差异，分别为P=0.004，P=0.001；Spearman分析验证了?琢-SMA与CAP呈负相关（r=-0.391）。IPGS＜5患者生存时间长于IPGS≥5患者（P=0.001）。［结论］ ?琢-SMA在IPGS≥5的OSCC患者中的表达显著强于IPGS＜5患者，胶原纤维表达与肌成纤维细胞的出现呈负相关。在OSCC中IPGS联合?琢-SMA和胶原纤维的表达可以作为OSCC患者的临床预后判断和诊断检测有价值的指标。 |
| 英文摘要: |
| Abstract：［Objective］ To investigate the expressions of collagen and muscle fibroblasts marker α-SMA in human oral squamous cell carcinoma（OSCC)，and their relation to invasive pattern and disease prognosis. ［Methods］ The invasive pattern grading score（IPGS) was examined by HE staining，the collagen fiber area percentage（CAP) was determined by Masson staining and the expression of α-SMA was detected by immunohistochemistry in 80 tissue specimens of OSCC. ［Results］ In 80 cases of OSCC，there were 32 cases with IPGS＜5 and 48 cases with IPGS≥5. There were significant differences in strongly positive rate of α-SMA or CAP between IPGS<5 group and ≥5 group（P=0.004，P=0.001，respectively）. Spearman analysis showed that there was a negative correlation between CAP and α-SMA（r=-0.391). The survival in IPGS<5 group was longer than that in IPGS ≥5 group（P=0.001）. ［Conclusion］ The results indicate that IPGS combining with α-SMA and collagen might be used as indicators for assessing clinical diagnosis and prognosis of OSCC. |
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