| 李 建,胥 润,吴雪莲.心理社会治疗对胃癌患者焦虑、抑郁情绪及免疫功能的影响[J].肿瘤学杂志,2016,22(9):722-726. |
| 心理社会治疗对胃癌患者焦虑、抑郁情绪及免疫功能的影响 |
| Effect of Psychosocial Treatment on Anxiety or Depression Status and Immune Function in Patients with Gastric Cancer |
| 投稿时间：2015-12-07 |
| DOI：10.11735/j.issn.1671-170X.2016.09.B007 |
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| 中文关键词: 胃肿瘤 抑郁 焦虑 免疫功能 |
| 英文关键词:gastric neoplasms depression anxiety immune function |
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| 中文摘要: |
| 摘 要：［目的］ 探讨心理社会治疗对胃癌患者焦虑、抑郁情绪及免疫功能的影响。［方法］ 将100例胃癌患者随机分为试验组和对照组各50例，在常规治疗的基础上，试验组同时接受心理社会治疗。于入院、术后1个月、术后3个月时采用汉密顿焦虑（HAMA）及抑郁量表（HAMD）评定患者的焦虑、抑郁状况，采用流式细胞术测定T淋巴细胞亚群、NK细胞比率及散射浊光计免疫法测定血清补体和免疫球蛋白含量。［结果］ 两组患者在术后1个月时HAMA及HAMD评分均较入院时升高，而在术后3个月时则逐渐下降，与对照组相比，试验组患者的焦虑、抑郁状况明显较轻（P＜0.05）。入院时试验组和对照组间T淋巴细胞亚群、NK细胞比率、血清补体和免疫球蛋白的差异无统计学意义（P＞0.05），术后1个月、3个月时试验组中CD3+、CD4+、NK细胞、CD4+/CD8+比值、血清补体和免疫球蛋白均比对照组高，而CD8+细胞比对照组低。［结论］ 在胃癌患者中，焦虑、抑郁是较普遍的并发症状，采取有针对性的心理社会干预，可以改善患者心理状况，提高患者免疫功能。 |
| 英文摘要: |
| Abstract：［Purpose］ To investigate the effect of psychosocial treatment on anxiety or depression status and immune function in patients with gastric cancer. ［Methods］ One hundred cases with gastric cancer were randomized into experimental group and control group，both with 50 cases and receiving conventional therapy，while psychosocial treatment was conducted additionally in experimental group. The anxiety and depression status were measured by the Hamilton Anxiety and Depression Scales(HAMA and HAMD) on admission，the T lymphocyte subsets and nature kill (NK) cells were determined by flow cytometry，and the plasma complements and immunoglobulins were determined using a nephelometric immunoassay. ［Results］ The scores of HAMA and HAMD were higher one month after operation than those on admission in both groups，which decreased three months after operation. Compared with the control group，the anxiety or depression status of the patients in the experimental group were significantly lower（P＜0.05）. There were no significant differences in the T lymphocyte subsets，NK cells，plasma complements and immunoglobulins between the two groups on admission（P＞0.05）. One and three months after operation，the CD3+，CD4+，NK cells，CD4+/CD8+ ratio，serum complements and immunoglobulins in the experimental group were higher while the CD8+ cell was less than those in the control group. ［Conclusion］ Anxiety and depression are common complications in patients with gastric cancer，and psychosocial treatment might significantly improve the psychological status of patients to up-regulate the immune function after operation. |
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