| 孙 云,胡晓杰,马国娟.胃癌组织中LMO1与Bcl-2、Bax、Survivin、Caspase-3蛋白表达的关系及意义[J].肿瘤学杂志,2016,22(9):703-707. |
| 胃癌组织中LMO1与Bcl-2、Bax、Survivin、Caspase-3蛋白表达的关系及意义 |
| Expression of LMO1 in Gastric Cancer Tissue and Its Relation to Cell Apoptosis |
| 投稿时间：2016-03-27 |
| DOI：10.11735/j.issn.1671-170X.2016.09.B003 |
|
 |
| 中文关键词: 胃肿瘤 LMO1 Bcl-2 Caspase-3 凋亡 |
| 英文关键词:gastric neoplasms LMO1 Bcl-2 Caspase-3 apoptosis |
| 基金项目: |
|
| 摘要点击次数: 1848 |
| 全文下载次数: 767 |
| 中文摘要: |
| 摘 要：［目的］ 检测LMO1、Bcl-2、Bax、Survivin、Caspase-3蛋白在胃癌组织中的表达，并对这些蛋白之间的关系和临床意义进行分析。 ［方法］ 对96例胃癌手术患者的肿瘤组织标本及50例癌旁组织标本进行免疫组化染色（SP法），检测LMO1、Bcl-2、Bax、Survivin、Caspase-3蛋白的表达情况。同时收集患者的病理学情况，对与各指标的关系进行分析。 ［结果］ 胃癌组织中LMO1、Bcl-2、Survivin表达均比癌旁组织增强（均P<0.05），Caspase-3蛋白在胃癌组织中表达低于癌旁组织（P<0.05），Bax在两种组织中表达无明显差异（P>0.05）。胃癌组织中细胞凋亡率明显低于癌旁组织（P<0.01）。胃癌组织中LOM1蛋白强表达者细胞凋亡率明显低于弱表达者（P<0.01）。Spearman相关分析发现，胃癌组织中LMO1与Bcl-2表达存在正相关（r=0.3058，P=0.002），LMO1与Caspase-3表达存在负相关（r=-0.2886，P=0.004）；Bcl-2与Survivin表达存在正相关关系（r=0.2986，P=0.0315），Bcl-2与Bax表达呈负相关（r=-0.4062，P<0.001），Survivin与Caspase-3也呈负相关（r=-0.3142，P=0.002）。［结论］ 胃癌组织中LMO1蛋白可能通过调节Bcl-2、Caspase-3的表达和活性而参与肿瘤凋亡。 |
| 英文摘要: |
| Abstract：［Objective］ To investigate the relationship between LMO1 expression and cell apoptosis in gastric cancer. ［Methods］ The expressions of LMO1 and apoptosis-related proteins Bcl-2，Bax，Survivin，Caspase-3 were detected immunohistochemically in 96 gastric cancer specimens and 50 adjacent tissue specimens. The relationship of LMO1 expression with cell apoptosis was analyzed. ［Results］ Expressions of LMO1，Bcl-2，Survivin proteins in gastric cancer tissues were stronger and expression of Caspase-3 protein was weaker than those in adjacent cancer tissues (all P<0.05)； no significant difference in Bax expression was found between gastric cancer tissues and adjacent cancer tissues(P>0.05). Apoptosis rate in gastric cancer tissues was lower than that in adjacent cancer tissues（P<0.01）. In gastric cancer tissues，apoptosis rate in cancer with positive expression of LOM1 was lower than that with negative expression of LOM1（P<0.01）.Spearman correlation analysis showed that positive correlation was found between LMO1 and Bcl-2（r=0.3058，P=0.002）；negative correlation was found between LMO1 and Caspase-3（r=-0.2886，P=0.004）；positive correlation was found between Bcl-2 and Survivin（r=0.3385，P=0.0141）；negative correlation was found between Bcl-2 and Bax（r=-0.4062，P<0.001），Survivin and Caspase-3（r=-0.3142，P=0.002）. ［Conclusion］ LMO1 protein might be involved in apoptosis of gastric cancer by regulating expression and activity of Bcl-2，caspase-3 proteins. |
|
在线阅读
查看全文 查看/发表评论 下载PDF阅读器 |