| 李美艳.171例子宫内膜癌患者预后因素分析[J].肿瘤学杂志,2016,22(7):543-548. |
| 171例子宫内膜癌患者预后因素分析 |
| Prognostic Factors of Endometrial Carcinoma：An Analysis of 171 Cases |
| 投稿时间：2016-01-08 |
| DOI：10.11735/j.issn.1671-170X.2016.07.B004 |
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| 中文关键词: 子宫内膜癌 骨桥蛋白 尿激酶型纤溶酶原激活物 预后 |
| 英文关键词:endometrial carcinoma osteopontin(OPN),urokinase-type plasminogen activator(uPA) prognosis |
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| 中文摘要: |
| 摘 要：［目的］ 探讨子宫内膜癌（endometrial carcinoma，EC）临床病理因素和生物学因素如骨桥蛋白（OPN）、尿激酶型纤溶酶原激活物（uPA）对EC手术预后的影响并筛选出最显著影响因素。［方法］ 选取171例经病理检查确诊为EC的患者，采用Kaplan-Meier法和Log-rank检验来评价各因素与EC患者生存时间的关系，并用Cox风险模型进行多因素分析。［结果］ 单因素分析显示手术—病理分期、肌层浸润深度、淋巴结转移、OPN阳性表达及uPA阳性表达5个因素与预后相关（P＜0.05），年龄、组织学分化、组织学类型与预后不相关（P＞0.05）。Cox多因素分析显示：手术—病理分期、肌层浸润深度、OPN阳性表达、uPA阳性表达是影响预后的独立因素。［结论］ 手术—病理分期晚、肌层浸润深、OPN表达阳性、uPA表达阳性的EC患者预后差，OPN和uPA有望成为反映EC生物学特性及评价EC预后的重要分子标记。 |
| 英文摘要: |
| Abstract：［Objective］ To investigate the factors related to prognosis of endometrial carcinoma (EC). ［Methods］ One hundred and seventy-one patients with pathologically confirmed endometrial carcinoma were included in the analysis. The overall survival of patients was evaluated by Kaplan-Meier method. The correlation of clinical features and laboratory findings with overall survival was assessed by univariate and multivariate analysis.［Results］ Univariate analysis showed that clinical and surgical stage，myometrial invasion，lymph node metastasis，positive expression of osteopontin(OPN) and urokinase-type plasminogen activator (uPA) were associated with prognosis(P<0.05)，while the age，histological differentiation and histological type were not associated with prognosis(P>0.05). Cox multivariate analysis showed that clinical and surgical stage，myometrial invasion，positive expression of OPN and uPA were the independent factors influencing the prognosis of EC patients.［Conclusion］ The EC patients with advanced clinical and surgical stage，deep myometrial invasion，positive expression of OPN and uPA would have poorer prognosis. |
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