| 徐洪恩,詹文明,杨 佳.直肠癌术后造口患者调强放疗计划的角度优化剂量学研究[J].肿瘤学杂志,2016,22(6):482-486. |
| 直肠癌术后造口患者调强放疗计划的角度优化剂量学研究 |
| The Study of Beam Angle Optimization in IMRT Plans for Postoperative Rectal Cancer Patients |
| 投稿时间：2016-03-09 |
| DOI：10.11735/j.issn.1671-170X.2016.06.B010 |
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| 中文关键词: 直肠肿瘤／放射疗法 适形调强放疗 射野角度优化 剂量学 |
| 英文关键词:rectal neoplasms/radiotherapy radiotherapy,intensity-modulated beam angle optimization dosimetry |
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| 中文摘要: |
| 摘 要：［目的］ 探讨在直肠癌术后造口患者术后放疗中，射野角度优化对调强放疗计划剂量分布及肠造口受量的影响。 ［方法］ 随机选取10例直肠癌术后造口患者，采用6野角度优化计划与7野角度均分调强计划进行比较，统计分析靶区(PTV)剂量分布及机器跳数、危及器官的受照剂量，分析不同计划的剂量学差异。 ［结果］ 与7野均分计划组相比，6野角度优化计划组PTVDmax、Dmean、Dmin、均匀指数差异无统计学意义(P＞0.05）；PTV适形指数稍劣于7野均分计划组（t=3.359，P<0.05）；6野角度优化计划的肠造口Dmax、Dmean均有显著降低（P<0.001），而小肠（V40、V30）、膀胱(V40、V30)、造口侧及对侧股骨头(V30)两组差异均无统计学意义；2组Mu数相似，差异无统计学意义（t=0.432，P＞0.05）。［结论］ 直肠癌术后造口患者放疗6野角度优化后的调强计划，降低了肠造口的受照剂量，基本保持与7野均分计划相当的靶区和危及器官的剂量学结果。 |
| 英文摘要: |
| Abstract：［Objective］ To explore the effect of beam angle optimization on intensity modulated radiation therapy (IMRT) plan in postoperative rectal cancer patients with stoma. ［Methods］ Ten postoperative rectal cancer patients with stoma were randomly enrolled. 6 beams angle optimization(6WO) was compared with 7 equiangular-spaced beams(7WD) IMRT plans. PTV dose distribution，monitor unit (Mu) and dose of organ at risk were calculated and dosimetric difference between each plans were analyzed.［Results］ There were no significant dosimetric differences of PTVDmax，Dmean，Dmin and comfort index (CI) compared 6WO with 7WD plan(P＞0.05）. 7WD plans showed significant advantage in PTV homogeneity index(HI). 6WO plan showed significant lower stoma Dmax and Dmean compared with 7WD plan（P<0.001）. But there was no significant difference in small intestine (V40，V30)，bladder (V40，V30)，femur (V30) and Mu among two different plans(P＞0.05）. ［Conclusions］ In postoperative rectal cancer patients with stoma receiving radiotherapy，6 beams angle optimization IMRT plan could reduce stoma dose and nearly keep the same target volume and dose for organ at risk with 7 equiangular-spaced beams plan. |
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