| 龙 斌,张丽军,叶 挺.基线刺激甲状腺球蛋白水平在预测甲状腺乳头状癌131I“清甲”疗效的价值[J].肿瘤学杂志,2016,22(6):473-477. |
| 基线刺激甲状腺球蛋白水平在预测甲状腺乳头状癌131I“清甲”疗效的价值 |
| Baseline Stimulated Thyroglobulin Level in Predicting Ablation Outcome for Patients with Papillary Thyroid Cancer Undergoing Radioiodine Remnant Ablation |
| 投稿时间：2016-02-23 |
| DOI：10.11735/j.issn.1671-170X.2016.06.B008 |
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| 中文关键词: 甲状腺肿瘤 放射性碘治疗 甲状腺球蛋白 |
| 英文关键词:thyroid neoplasms radioiodine therapy thyroglobulin |
| 基金项目:浙江省医药卫生科技计划一般项目（2015KYB058） |
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| 中文摘要: |
| 摘 要：［目的］ 探讨甲状腺乳头状癌术后TSH刺激状态下甲状腺球蛋白（STg）水平预测131I清甲疗效的价值。［方法］回顾性分析首次131I清甲治疗的138例甲状腺乳头状癌患者资料，其中男性35例，女性103例，中位年龄（45.69±11.93）岁，分析基线STg水平对清甲成功（清甲后6~12个月STg＜1ng/ml 、DxWBS未见甲状腺床摄碘、颈部超声未见甲状腺残留）的预测价值。［结果］ 总清甲成功率为73.9%（102/138），清甲成功组与失败组基线STg值分别为（7.82±10.57）ng/ml、（57.97±97.56）ng/ml，两者具有统计学差异（t=-5.14，P＜0.001），采用ROC曲线分析STg截断值为12.8ng/ml，当STg≤12.8ng/ml时，其预测清甲成功的灵敏度、特异性、阳性预测值、阴性预测值分别为63.89%、83.33%、91.56%、44.90%，结果显示86.6%(84/97)STg≤12.8ng/ml患者和43.9%(18/41)STg＞12.8ng/ml患者清甲成功。［结论］ 甲状腺乳头状癌术后131I治疗前TSH刺激下Tg水平是一个可靠的预测清甲疗效的指标。 |
| 英文摘要: |
| Abstract：［Objective］ To investigate the predicting value of baseline stimulated thyroglobulin(STg) level for ablation outcome in patients with papillary thyroid cancer(PTC) undergoing radioiodine remnant ablation (RRA). ［Methods］ Clinical data of 138 PTC patients including 35 males and 103 females with mean age of 45.69±11.93 years，who underwent total thyroidectomy followed by RRA，were retrospectively analyzed. The successful ablation was defined as STg<1ng/ml，negative finding in whole body iodine scan(DxWBS) and neck ultrasonography at 6~12 months after RRA. The predictive value of baseline STg level for successful RRA was analyzed.［Results］ The overall successful ablation rate was 73.9%(102/138). The mean baseline STg levels in successful ablation group and failure group were (7.82±10.57)ng/ml and (57.97±97.56)ng/ml，respectively(t=-5.14，P<0.001). Using baseline STg≤12.8ng/ml as cut-off value for predicting successful ablation，the sensitivity，specificity，positive predictive value and negative predictive value were 63.89%，83.33%，91.56% and 44.90%，respectively. Successful ablation was found in 86.6% (84/97) of patients with baseline STg≤12.8ng/ml and 43.9% (18/41) patients with baseline STg>12.8ng/ml. ［Conclusion］ The baseline STg level may be used for prediction of successful ablation in PTC patients with total thyroidectomy followed by RRA. |
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