| 杨惠萍,陈 婷,应苗法.重组人血管内皮抑制素联合顺铂腔内注射治疗恶性胸腔积液疗效和安全性的Meta分析[J].肿瘤学杂志,2016,22(5):410-416. |
| 重组人血管内皮抑制素联合顺铂腔内注射治疗恶性胸腔积液疗效和安全性的Meta分析 |
| Efficacy and Safety of Combination of Recombinant Human Endostatin and Cisplatin in Treatment of Malignant Pleural Effusion：A Meta-analysis |
| 投稿时间：2016-01-23 |
| DOI：10.11735/j.issn.1671-170X.2016.05.B015 |
|
 |
| 中文关键词: 重组人血管内皮抑制素 顺铂 腔内注射 胸腔积液 Meta分析 |
| 英文关键词:recombinant human endostatin cisplatin intrapleural instillation pleural effusion Meta-analysis |
| 基金项目: |
|
| 摘要点击次数: 1620 |
| 全文下载次数: 886 |
| 中文摘要: |
| 摘 要：［目的］系统评价重组人血管内皮抑制素联合顺铂腔内注射治疗恶性胸腔积液的有效性和安全性。［方法］ 计算机检索PubMed、Cochrane图书馆、中国学术文献出版总库（CNKI）、维普电子期刊全文数据库（VIP）、万方数据库（Wanfang Database）、中国生物医学文献数据库（CBM）等。2名评价员独立评价纳入研究的质量并提取资料，使用RevMan5.3软件进行统计分析。［结果］共纳入20个研究，共1271例患者。Meta分析结果显示：重组人血管内皮抑制素联合顺铂能提高恶性胸腔积液治疗的有效率（OR=3.95，95%CI：3.09~5.05，P<0.00001），改善患者的生活质量（OR=3.33，95%CI：2.55~4.36，P<0.00001），对骨髓抑制、胃肠道副作用等不良反应的发生率无显著性影响。［结论］重组人血管内皮抑制素联合顺铂腔内注射能改善治疗效果且安全性良好。 |
| 英文摘要: |
| Abstract：［Ｏbjective］ To evaluate the efficacy and safety of intrapleural instillation of recombinant human endostatin and cisplatin for malignant pleural effusion by meta-analysis. ［Methods］ Random controlled trails(RCTs) on combined instillation of endostatin and cisplatin in treatment of malignant effusion were searched from database Pubmed，the Cochrane Library，CNKI，VIP，Wanfang Database and CBM. The data was collected and the quality of included RCTs was evaluated by 2 evaluators independently. Meta-analysis was performed using RevMan5.3. ［Results］ Twenty RCTs involving 1271 participants were included. The result of Meta-analysis indicated that intrapleural instillation of recombinant human endostatin and cisplatin improved treatment efficacy(OR=3.95，95%CI：3.09～5.05，P<0.00001) and the quality of life of patients(OR=3.33，95%CI：2.55～4.36，P<0.00001). The adverse effects，including bone marrow depression and gastrointestinal tract toxicity did not affect the treatment significantly.［Conclusion］ Intrapleural instillation of recombinant human endostatin and cisplatin is effective and safe in treatment of malignant pleural effusion. |
|
在线阅读
查看全文 查看/发表评论 下载PDF阅读器 |