| 张艳娇,高禹舜,毛友生.胸腔镜解剖性肺段切除术治疗ⅠA期非小细胞肺癌对肺功能的影响[J].肿瘤学杂志,2016,22(5):389-393. |
| 胸腔镜解剖性肺段切除术治疗ⅠA期非小细胞肺癌对肺功能的影响 |
| Pulmonary Function Changes After Video-assisted Thoracoscopic Anatomic Segmentectomy for Stage ⅠA Non-small Cell Lung Cancer |
| 投稿时间：2016-03-26 |
| DOI：10.11735/j.issn.1671-170X.2016.05.B011 |
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| 中文关键词: 非小细胞肺癌 肺功能 肺段手术 胸腔镜 |
| 英文关键词:non-small cell lung cancer pulmonary function anatomic segmentectomy video-assisted thoracic surgery |
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| 中文摘要: |
| 摘 要：［目的］ 研究非小细胞肺癌（NSCLC）胸腔镜肺段切除术后肺功能的损伤情况。［方法］对68例ⅠA期NSCLC患者，行2次以上肺功能检查，分别于术前与术后第3d和或术后3个月测试肺功能。术后第3d天测试肺功能的44例患者为A组，术后3个月测试肺功能的24例患者为B组。［结果］ 两组术前肺功能没有差异。A组术后第3d肺功能水平：用力肺活量（forced vital capacity，FVC）为（1.46±0.56）L，FVC%为41.58%±10.56%，1秒用力呼气容积（forced expiratory volume in one second，FEV1）为（1.31±0.50）L，FEV1%为46.35%±12.09%，FEV1/FVC（%）为89.78%±5.71%，最大呼气流速峰值（peak expiratory flow，PEF）为（2.94±1.42）L/s，每分钟最大通气量（maximal voluntary ventilation，MVV）为(49.29±4.23)L/min，肺一氧化碳弥散因子（transfer factor for carbon monoxide of lung，TLCO）为（4.04±1.08）mmol/min/kPa，TLCO%为48.40%±11.12%，比术前降低明显（P<0.05）。B组术后3个月肺功能水平：FVC为（2.88±1.02）L，FVC%为81.19%±14.46%，FEV1为（2.36±0.84）L，FEV1%为82.74%±15.09%，FEV1/FVC（%）为82.23%±10.13%，PEF为（5.17±1.89）L/s，MVV为(83.00±29.58)L/min，TLCO为（7.10±1.58）mmol/min/kPa，TLCO%为77.00%±24.24%，相比A组第3d肺功能水平有所提高。［结论］ 肺癌胸腔镜肺段切除在术后极早期（术后3d）与术前相比，肺功能损伤较大。术后3个月时，患者的肺功能很可能可以达到正常水平，但与术前相比还有一定的差距。 |
| 英文摘要: |
| Abstract：［Objective］ To assess the pulmonary function after video-assisted thoracoscopic (VATS) anatomic segmentectomy for patients with stage ⅠA non-small cell lung cancer(NSCLC). ［Methods］ Sixty eight patients with stage ⅠA NSCLC underwent VATS anatomic segmentectomy. The pulmonary function was determined before surgery and 3 days(group A，n=44) or 3 months after surgery (group B，n=24). ［Results］ There was no significant difference in pulmonary function between two groups before operation. In group A，the pulmonary function 3 days after the surgery were：forced vital capacity (FVC)（1.46±0.56）L，FVC% 41.58%±10.56%，forced expiratory volume in one second (FEV1)（1.31±0.50）L，FEV1% 46.35%±12.09%，FEV1/FVC（%）89.78%±5.71%，peak expiratory flow (PEF)（2.94±1.42）L/s，maximal voluntary ventilation (MVV) (49.29±4.23)L/min，transfer factor for carbon monoxide of lung (TLCO)（4.04±1.08）mmol/min/kPa，TLCO% 48.40%±11.12%，all of which were decreased significantly than those before operation(P<0.05). In group B the pulmonary function 3 months after the surgery were：FVC （2.88±1.02）L，FVC%81.19%±14.46%，FEV1（2.36±0.84）L，FEV1% 82.74%±15.09%，FEV1/FVC（%）82.23%±10.13%，PEF（5.17±1.89）L/s，MVV (83.00±29.58)L/min，TLCO（7.10±1.58）mmol/min/kPa，TLCO%77.00%±24.24%，all of which were higher than those in group A 3 days after operation. ［Conclusion］ The pulmonary function indicators shortly after the surgery are markedly lower than preoperative levels. After recovery for 3 months，the pulmonary function would be close to the normal value but still lower than preoperative level. |
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