| 叶 静,朱阿考,张方捷.长链非编码RNA HOTAIR在胃肠间质瘤中的表达特点及其意义[J].肿瘤学杂志,2016,22(5):380-383. |
| 长链非编码RNA HOTAIR在胃肠间质瘤中的表达特点及其意义 |
| Expression of Long Non-coding RNA HOTAIR and Its Significance in Gastrointestinal Stromal Tumors |
| 投稿时间：2016-03-02 |
| DOI：10.11735/j.issn.1671-170X.2016.05.B009 |
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| 中文关键词: 长链非编码RNA HOTAIR 胃肠间质瘤 |
| 英文关键词:long non-coding RNA HOTAIR gastrointestinal stromal tumor |
| 基金项目:浙江省卫生厅一般项目A类（2015118181） |
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| 中文摘要: |
| 摘 要：［目的］ 研究长链非编码RNA HOTAIR在胃肠间质瘤中的表达特点以及临床病理意义，并分析与胃肠间质瘤患者预后的关系。［方法］ 应用实时定量PCR检测59例胃肠间质瘤肿瘤标本中HOTAIR表达水平，分析胃肠间质瘤中HOTAIR表达水平与肿瘤危险程度、核分裂相以及预后之间的相关性。［结果］ 胃肠道间质瘤中HOTAIR表达与肿瘤危险分度、核分裂相、肿瘤多发呈明显相关，HOTAIR高、低表达组2年生存率分别为96.0%、69.2%，两组比较差异有统计学意义（P=0.024）。［结论］ 长链非编码RNA HOTAIR与胃肠间质瘤肿瘤恶性程度和预后有关；HOTAIR作为抑癌非编码基因有望成为胃肠间问质瘤诊断以及预后判断的重要指标。 |
| 英文摘要: |
| Abstract：［Objective］ To investigate the expression of long non-coding RNA HOTAIR and its clinicopathological significance in gastrointestinal stromal tumor(GIST). ［Methods］ The expression levels of HOTAIR in 59 GIST samples were detected by real-time polymerase chain reaction (RT-PCR)，and the correlation of HOTAIR expression with cancer risk grade，mitotic count and prognosis was analyzed. ［Results］ The expression of HOTAIR was significantly correlated with cancer risk grade，mitotic count and multiple tumors. The 2-year survival rate in patients with high HOTAIR expression was significantly higher than those with low HOTAIR expression (96.0% and 69.2%，P=0.024). ［Conclusion］ Long non-coding RNA HOTAIR is correlated with malignant degree and prognosis of GIST，indicating that it may be used for diagnosis and prognosis of GIST. |
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