| 刘 佳,李文忠,夏秀娟.转移性结直肠癌维持治疗的进展[J].肿瘤学杂志,2016,22(5):344-348. |
| 转移性结直肠癌维持治疗的进展 |
| Progress on Maintenance Therapy for Metastatic Colorectal Cancer |
| 投稿时间：2015-06-29 |
| DOI：10.11735/j.issn.1671-170X.2016.05.B002 |
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| 中文关键词: 结直肠肿瘤 维持治疗 药物疗法 靶向治疗 |
| 英文关键词:colorectal neoplasms maintenance therapy drug therapy targeted therapy |
| 基金项目: |
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| 中文摘要: |
| 摘 要：目前，转移性结直肠癌（metastatic colorectal cancer，mCRC）的标准一线治疗方案是在化疗药物基础上联合分子靶向药物。对于完成一线治疗且达到完全缓解、部分缓解或稳定的转移性结直肠癌患者，与持续化疗或单纯观察相比，维持治疗不仅可以巩固一线治疗疗效，延缓疾病进展，而且可以减轻化疗药物的蓄积性不良反应，改善患者生存质量，最终达到延长总生存期的目的。维持治疗包括化疗药物、分子靶向药物和化疗药物联合分子靶向药物维持治疗3种方式，近年来已成为转移性结直肠癌研究的重要方向，但仍有许多问题尚待进一步探索和研究。 |
| 英文摘要: |
| Abstract：At present，the standard first-line treatment of metastatic colorectal cancer is based on chemotherapy in combination with molecular targeted drugs.For these patients achieving an objective response or stable disease after first-line treatment，compared with the continuous chemotherapy or observation alone，maintenance therapy can not only consolidate the efficacy of first-line treatment and improve progression-free survival，but also can decrease the cumulative toxicity of chemotherapy，enhance the quality of life，and ultimately prolong overall survival.Maintenance therapy has three strategies，including the treatment with chemotherapy drugs，molecular targeted drugs，and chemotherapy drugs plus targeted drugs.In recent years，it has become an important trend of metastatic colorectal cancer，but there are still many problems to be further explored and studied. |
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