| 王 熙,耿圆圆,侯 蔷.细菌磁小体作为新型非病毒载体用于肿瘤基因治疗的研究进展[J].肿瘤学杂志,2016,22(4):322-326. |
| 细菌磁小体作为新型非病毒载体用于肿瘤基因治疗的研究进展 |
| Research Progress in Magnetosomes Used as a New Non-viral Vector for Tumor Gene Therapy |
| 投稿时间：2015-09-06 |
| DOI：10.11735/j.issn.1671-170X.2016.04.B014 |
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| 中文关键词: 细菌磁小体 肿瘤 基因治疗 载体 |
| 英文关键词:bacterial magnetosomes tumor gene therapy vector |
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| 中文摘要: |
| 摘 要：磁小体是由趋磁细菌自身生物矿化形成的纳米级单磁畴晶体，其主要成分为Fe3O4，以脂膜包裹。磁小体晶型完美、粒径均一、有良好的分散性、分布范围窄等特点，可作为一种纳米载体应用于多种活性物质的固定负载。且由于磁小体具有良好的生物相容性及表面可修饰等显著优势，故在肿瘤靶向治疗方面有着广阔的应用前景。本文主要介绍了基因治疗的研究现状、细菌磁小体的特性以及将磁小体作为非病毒载体用于肿瘤基因治疗的优势和应用，并探讨了磁小体作为一种新型非病毒载体的发展前景。 |
| 英文摘要: |
| Abstract：Bacterial magnetosomes(BMs) are nanoparticles with single domain biosynthesized in magnetotactic bacteria. They are composed of Fe3O4 crystals enveloped by an organic membrane. They are highly crystalline，monodisperse，with nano-scale and narrow size distribution. Magnetosomes have been commonly used as a novel natural magnetic nanocarrier for various bioactive substances due to its significant advantages such as the characteristics above. Furthermore，as their biocompatibility and surface modification，a broad application prospect in tumor gene therapy was emerged. In this review，the features and advantages of magnetosomes，especially their application study on tumor gene therapy as a non-viral vector are introduced in detail. |
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