宁召锋,李 梁,刘 霞.DNA聚合酶β表达对食管癌放疗敏感性及预后的影响[J].肿瘤学杂志,2016,22(4):305-309. |
DNA聚合酶β表达对食管癌放疗敏感性及预后的影响 |
The Influence of DNA Polymerase Beta Expression on the Susceptibility to Esophageal Cancer Radiation Therapy and Prognosis |
投稿时间:2015-10-27 |
DOI:10.11735/j.issn.1671-170X.2016.04.B011 |
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中文关键词: 食管肿瘤 DNA聚合酶β 放射疗法 |
英文关键词:esophageal neoplasms DNA polβ radiotherapy |
基金项目:山东省泰安市科技发展专项计划(201440774-43B) |
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中文摘要: |
摘 要:[目的] 探讨DNA聚合酶β表达对食管癌放疗敏感性的影响及预后评估。[方法] 收集85例食管癌患者,根据DNA聚合酶β(DNA polβ)的表达水平随机分为高表达常规分割组、高表达超分割组、低表达常规分割组和低表达超分割四组。常规分割:2Gy/f,总量56~64Gy/28~32次,超分割:1.3 Gy/f,2f/d,总量56~62Gy/43~48次。治疗中及治疗后随访,观察急性反应、晚期反应以及近期疗效、局控率及1、3年生存率。[结果] 四组之间放疗晚期反应肺纤维化及食管狭窄差别无统计学意义(P=0.887、0.711);近期疗效差异无统计学意义(P=0.862);急性反应放射性气管炎、放射性食管炎差异有意义(P=0.049、0.031),超分割两组显著高于常规分割组;1、3年局部控制率及生存率两组差异明显(P=0.028、0.036、0.040、0.014)。[结论] 超分割放疗加重急性反应,DNA polβ表达不同对放疗敏感性有影响,低表达组超分割放疗预后相对较好。 |
英文摘要: |
Abstract:[Objective] To explore the influence of DNA polymerase beta expression on the susceptibility to esophageal cancer radiotherapy and prognostic. [Methods] A total of 85 patients were divided into four groups according to the expression of polβ:high expression of conventional segmentation group,high expression of hyperfractionation groups,lower expression of conventional segmentation group and lower expression of hyperfractionation group. Conventional fractionation group:2Gy/f,DT 56~64Gy/28~32f. Hyperfractionated group:1.3Gy/f,2f/d,DT 56~62Gy/43~48f. The acute reaction,late effects,short-term effects,local control rate and 1-,3-year survival rate were observed. [Results] Late radiation pulmonary fibrosis and esophageal stenosis had no significant difference in the 4 groups(P=0.887,0.711). The recent curative effect had no significant difference (P=0.862). Acute radioactive reaction tracheitis,radioactive esophagitis had significant difference(P=0.049,0.031). 1-,3-year local control and survival rate had obvious difference(P=0.028,0.036, 0.040,0.036). [Conclusion] Super segmentation radiation might increase acute reaction. Different expression of DNA pol beta may affect sensitivity to radiotherapy. Ultra low expression group divided radiotherapy has a better prognosis. |
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