| 高 光,金仁顺.SP和CDX2表达的胃黏膜上皮化生与胃癌的关系研究[J].肿瘤学杂志,2016,22(4):291-295. |
| SP和CDX2表达的胃黏膜上皮化生与胃癌的关系研究 |
| Relationship Between SP and CDX2 Expressed Gastric Metaplasia and Gastric Carcinoma |
| 投稿时间：2015-02-26 |
| DOI：10.11735/j.issn.1671-170X.2016.04.B008 |
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| 中文关键词: 胃黏膜化生 胃肿瘤 SP CDX2 |
| 英文关键词:gastricmucosa metaplasia gastric neoplasms SP CDX2 |
| 基金项目:吉林省教育厅课题（吉教科合字2012第6号） |
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| 中文摘要: |
| 摘 要：［目的］ 探讨解痉多肽（SP）表达阳性的胃黏膜化生和尾型同源盒转录因子2（CDX2）表达阳性的肠上皮化生与贲门癌和胃窦癌的关系。［方法］ 收集胃贲门癌标本39例，胃窦癌标本40例，采用免疫组织化学染色方法观察SP和CDX2在贲门癌和胃窦癌组织及其相关癌旁组织中的表达。［结果］ SP在贲门癌及癌旁组织中的表达率分别为33.3%和64.1%（P=0.007）。在胃窦癌及其癌旁组织中的表达率分别为10.0%和30.0% (P=0.025)。CDX2在胃窦癌及其癌旁组织中的表达率分别为70.0%和42.5%(P=0.013)。在贲门癌及癌旁组织中的表达率分别为20.5%和12.8%（P=0.362）。SP和CDX2在贲门癌和胃窦癌组织及其相关癌旁组织中的表达均存在明显的统计学差异。进一步的临床病理学指标分析显示CDX2阳性表达与胃癌的组织学分化程度有关(P=0.013)。［结论］ SP和CDX2表达阳性的不同类型胃黏膜化生性病变均与贲门癌和胃窦癌的发生有关。 |
| 英文摘要: |
| Abstract：［Objective］ To explore the association between the expressions of SP and CDX2 and gastric carcinoma.［Methods］ Thirty-nine gastric cardia carcinoma (GCC) and 40 gastricantral carcinoma (GAC) specimens were analyzed. The expressions of SP and CDX2 were determined by two-step immunohistochemical method.［Results］ The expression rates of SP were 33.3% and 64.1% in GCC and adjacent tissues（P=0.007），10.0% and 30.0% in GAC and adjacent tissues(P=0.025). CDX2 expression were positive in 70.0% GAC and 42.5% adjacent tissues (P=0.013)，and were positive in 20.5% GCC and 12.8% adjacent tissues（P=0.362）. SP and CDX2 expressed significantly different in GCC，GAC and related adjacent tissues. In addition，clinicopathologic analysis showed that the expression of CDX2 was associated with histological type of gastric carcinoma(P=0.013).［Conclusions］ The expressions of SP and CDX2 in gastric metaplasia lesions may be related with gastric carcinoma. |
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